TAU Nanocenter

Multiple catalytic oxidation processes involving new synthesized materials have recently been examined to replace conventional oxidative treatment methods for water purification, but upscaling and demonstration stages are mostly lacking, which hinders their practical implementation. In this study, we introduce a novel catalytic process where peroxymonosulfate (PMS) is activated by MnO2 surfaces that are attached on natural sand as part of a catalytic filtration column (CFC). PMS decomposition in the CFC was stable during steady-state filter operation with different natural waters (tap water and secondary effluent) and sulfate radicals were identified as main radical species. Complete oxidation (>99 %) of 10 mg/L rhodamine B in tap water could be achieved with PMS concentrations as low as 0.2 mM and a residence time of less than 3 min. Furthermore, unselective oxidation of various recalcitrant and …

Constantly raising microplastic (MP) contamination of water sources poses a direct threat to the gentle balance of the marine environment. This study focuses on a multifactor hazard evaluation of conventional (polyethylene - PE, polypropylene - PP, and polystyrene - PS) and alternative (polyethylene terephthalate with 25 % or 50 % recycled material and polylactic acid) plastics. The risk assessment framework explored included MP abundance, water acidification potential, surface oxidation, fragmentation, and bacterial growth inhibition. Based on MP monitoring campaigns worldwide, we conclude that PE-based plastics are the most abundant MPs in water samples (comprise up to 82 % the MP in those samples). A year-long weathering experiment showed that PS-based and PP-based plastics were oxidized to a higher extent, resulting in the highest water acidification with pH reduction of up to three orders of …

Multiple catalytic oxidation processes involving new synthesized materials have recently been examined to replace conventional oxidative treatment methods for water purification, but upscaling and demonstration stages are mostly lacking, which hinders their practical implementation. In this study, we introduce a novel catalytic process where peroxymonosulfate (PMS) is activated by MnO2 surfaces that are attached on natural sand as part of a catalytic filtration column (CFC). PMS decomposition in the CFC was stable during steady-state filter operation with different natural waters (tap water and secondary effluent) and sulfate radicals were identified as main radical species. Complete oxidation (>99 %) of 10 mg/L rhodamine B in tap water could be achieved with PMS concentrations as low as 0.2 mM and a residence time of less than 3 min. Furthermore, unselective oxidation of various recalcitrant and …

The survival and function of tissues depend on appropriate vascularization. Blood vessels of the tissues supply oxygen, and nutrients and remove waste and byproducts. Incorporating blood vessels into engineered tissues is essential for overcoming diffusion limitations, improving tissue function, and thus facilitating the fabrication of thick tissues. Here, we present a modified ECM bioink, with enhanced mechanical properties and endothelial cell-specific adhesion motifs, to serve as a building material for 3D printing of a multiscale blood vessel network. The bioink is composed of natural ECM and alginate conjugated with a laminin adhesion molecule motif (YIGSR). The hybrid hydrogel was characterized for its mechanical properties, biochemical content, and ability to interact with endothelial cells. The pristine and modified hydrogels were mixed with induced pluripotent stem cells derived endothelial cells (iPSCs-ECs) and used to print large blood vessels with capillary beds in between.

The survival and function of tissues depend on appropriate vascularization. Blood vessels of the tissues supply oxygen, and nutrients and remove waste and byproducts. Incorporating blood vessels into engineered tissues is essential for overcoming diffusion limitations, improving tissue function, and thus facilitating the fabrication of thick tissues. Here, we present a modified ECM bioink, with enhanced mechanical properties and endothelial cell-specific adhesion motifs, to serve as a building material for 3D printing of a multiscale blood vessel network. The bioink is composed of natural ECM and alginate conjugated with a laminin adhesion molecule motif (YIGSR). The hybrid hydrogel was characterized for its mechanical properties, biochemical content, and ability to interact with endothelial cells. The pristine and modified hydrogels were mixed with induced pluripotent stem cells derived endothelial cells (iPSCs-ECs) and used to print large blood vessels with capillary beds in between.

Constantly raising microplastic (MP) contamination of water sources poses a direct threat to the gentle balance of the marine environment. This study focuses on a multifactor hazard evaluation of conventional (polyethylene - PE, polypropylene - PP, and polystyrene - PS) and alternative (polyethylene terephthalate with 25 % or 50 % recycled material and polylactic acid) plastics. The risk assessment framework explored included MP abundance, water acidification potential, surface oxidation, fragmentation, and bacterial growth inhibition. Based on MP monitoring campaigns worldwide, we conclude that PE-based plastics are the most abundant MPs in water samples (comprise up to 82 % the MP in those samples). A year-long weathering experiment showed that PS-based and PP-based plastics were oxidized to a higher extent, resulting in the highest water acidification with pH reduction of up to three orders of …

In article number 2302229, Tal Dvir and co-workers demonstrate a biocompatible method for reinforcing engineered tissue post-fabrication. The technique enables 3D bioprinting of soft tissue and gives the cells time to establish intercellular communications before the tissue's mechanical properties are significantly improved by the reinforcement protocol. In the work, thick, vascularized cardiac tissues are enhanced to the point of injectability.

Nonlinear photonic crystals (NPCs) with spatially modulated second‐order nonlinear coefficients are indispensable in nonlinear optics and modern photonics. To access full degrees of freedom in the generation and control of coherent light at new frequencies, three dimensional (3D) NPCs have been recently fabricated employing the femtosecond laser writing technique in ferroelectric crystals. However, the nonlinear interaction efficiencies in 3D NPCs so far are rather low, which has been a major barrier to further development. Here, fabrication challenges of large‐scale 3D NPCs have been overcome to realize more than four orders of magnitude efficiency improvement over previously reported crystals. With the generation of second harmonic vortex beam as an example, the measured conversion efficiencies as high as 2.9 × 10−6 W−1 (femtosecond pulse‐pumped) and 1.2 × 10−5 W−1 (continuous‐wave …

Multimode bright squeezed vacuum is a non-classical state of light hosting a macroscopic photon number while offering promising capacity for encoding quantum information in its spectral degree of freedom. Here, we employ an accurate model for parametric down-conversion in the high-gain regime and use nonlinear holography to design quantum correlations of bright squeezed vacuum in the frequency domain. We propose the design of quantum correlations over two-dimensional lattice geometries that are all-optically controlled, paving the way toward continuous-variable cluster state generation on an ultrafast timescale. Specifically, we investigate the generation of a square cluster state in the frequency domain and calculate its covariance matrix and the quantum nullifier uncertainties, that exhibit squeezing below the vacuum noise level.

Optical orbital angular momentum (OAM) is studied these days in numerous fundamental and applicative scenarios, including for example space division-multiplex optical communication, quantum communication and particle manipulation. The shape of OAM beams depends both on the transverse coordinates and on the propagation coordinate thus exhibiting rotational energy flows that vary in three-dimensional (3D) space [1]. Despite decades of research in the field of OAM, these 3D energy flows remained experimentally hidden. This is because symmetry breaking, that allows a glimpse to the rotational nature of these flows, changes the beam shape and destructs its original “fluid” like flow.

Multimode bright squeezed vacuum is a non-classical state of light hosting a macroscopic photon number while offering promising capacity for encoding quantum information in its spectral degree of freedom. Here, we employ an accurate model for parametric downconversion in the high-gain regime and use nonlinear holography to design quantum correlations of bright squeezed vacuum in the frequency domain. We propose the design of quantum correlations over two-dimensional lattice geometries that are all-optically controlled, paving the way toward continuous-variable cluster state generation on an ultrafast timescale. Specifically, we investigate the generation of a square cluster state in the frequency domain and calculate its covariance matrix and the quantum nullifier uncertainties, that exhibit squeezing below the vacuum noise level.

We propose and analyze a new paradigm for optical quantum computation using anharmonic photonic cavity qubits and free-electron ancillas. Our approach enables deterministic, high-fidelity quantum gates and preparation of cluster states between remote cavities.

In myocardial infarction, a blockage in one of the coronary arteries leads to ischemic conditions in the left ventricle of the myocardium and, therefore, to significant death of contractile cardiac cells. This process leads to the formation of scar tissue, which reduces heart functionality. Cardiac tissue engineering is an interdisciplinary technology that treats the injured myocardium and improves its functionality. However, in many cases, mainly when employing injectable hydrogels, the treatment may be partial because it does not fully cover the diseased area and, therefore, may not be effective and even cause conduction disorders. Here, we report a hybrid nanocomposite material composed of gold nanoparticles and an extracellular matrix-based hydrogel. Such a hybrid hydrogel could support cardiac cell growth and promote cardiac tissue assembly. After injection of the hybrid material into the diseased area of the heart, it could be efficiently imaged by magnetic resonance imaging (MRI). Furthermore, as the scar tissue could also be detected by MRI, a distinction between the diseased area and the treatment could be made, providing information about the ability of the hydrogel to cover the scar. We envision that such a nanocomposite hydrogel may improve the accuracy of tissue engineering treatment.

We propose a novel, physically-constrained and differentiable approach for the generation of D-dimensional qudit states via spontaneous parametric down-conversion (SPDC) in quantum optics. We circumvent any limitations imposed by the inherently stochastic nature of the physical process and incorporate a set of stochastic dynamical equations governing its evolution under the SPDC Hamiltonian. We demonstrate the effectiveness of our model through the design of structured nonlinear photonic crystals (NLPCs) and shaped pump beams; and show, theoretically and experimentally, how to generate maximally entangled states in the spatial degree of freedom. The learning of NLPC structures offers a promising new avenue for shaping and controlling arbitrary quantum states and enables all-optical coherent control of the generated states. We believe that this approach can readily be extended from bulky crystals to thin Metasurfaces and potentially applied to other quantum systems sharing a similar Hamiltonian structures, such as superfluids and superconductors.

We study here the intensity distribution and formation of optical polarization Möbius strips by tightly focusing of C-point singularity beams. These beams are characterized by a central circular polarization point (C-point) surrounded by a spatially varying elliptic polarization. Under tight focusing conditions, the different polarization components of the beam interfere and exhibit clear difference between left-handed and right handed input beams. The transverse polarization distribution at the focal plane is similar to the input distribution for left-handed lemon beam, but exhibits 180 rotation for right handed lemon beam. Moreover, the longitudinal polarization component exhibits spiral phase distribution, owing to spin-orbit angular momentum conversion at the focal plane, with opposite winding directions for the left-handed and right-handed input beams. We show that the shape of the resulting Möbius strip is determined …

Despite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, we present a method for reinforcing an engineered cardiac tissue fabricated from differentiated iPSCs and an ECM‐based hydrogel in a manner that is fully biocompatible. The reinforcement occurs as a post‐fabrication step, which allows for the use of 3D printing technology to generate thick, fully cellularized, and vascularized cardiac tissues. After tissue assembly and during the maturation process in a soft hydrogel, a small, tissue‐penetrating reinforcer is deployed, leading to a significant increase in the tissue's mechanical properties. The tissue's robustness is demonstrated by injecting the tissue in a simulated minimally invasive procedure and showing that the tissue is functional and undamaged at the nano‐, micro …

Despite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, we present a method for reinforcing an engineered cardiac tissue fabricated from differentiated iPSCs and an ECM‐based hydrogel in a manner that is fully biocompatible. The reinforcement occurs as a post‐fabrication step, which allows for the use of 3D printing technology to generate thick, fully cellularized, and vascularized cardiac tissues. After tissue assembly and during the maturation process in a soft hydrogel, a small, tissue‐penetrating reinforcer is deployed, leading to a significant increase in the tissue's mechanical properties. The tissue's robustness is demonstrated by injecting the tissue in a simulated minimally invasive procedure and showing that the tissue is functional and undamaged at the nano‐, micro …

We propose a novel, physically-constrained and differentiable approach for the generation of D-dimensional qudit states via spontaneous parametric down-conversion (SPDC) in quantum optics. We circumvent any limitations imposed by the inherently stochastic nature of the physical process and incorporate a set of stochastic dynamical equations governing its evolution under the SPDC Hamiltonian. We demonstrate the effectiveness of our model through the design of structured nonlinear photonic crystals (NLPCs) and shaped pump beams; and show, theoretically and experimentally, how to generate maximally entangled states in the spatial degree of freedom. The learning of NLPC structures offers a promising new avenue for shaping and controlling arbitrary quantum states and enables all-optical coherent control of the generated states. We believe that this approach can readily be extended from bulky crystals to thin Metasurfaces and potentially applied to other quantum systems sharing a similar Hamiltonian structures, such as superfluids and superconductors.

Cavity quantum electrodynamics (QED), wherein a quantum emitter is coupled to electromagnetic cavity modes, is a powerful platform for implementing quantum sensors, memories, and networks. However, due to the fundamental tradeoff between gate fidelity and execution time, as well as limited scalability, the use of cavity-QED for quantum computation was overtaken by other architectures. Here, we introduce a new element into cavity-QED - a free charged particle, acting as a flying qubit. Using free electrons as a specific example, we demonstrate that our approach enables ultrafast, deterministic and universal discrete-variable quantum computation in a cavity-QED-based architecture, with potentially improved scalability. Our proposal hinges on a novel excitation blockade mechanism in a resonant interaction between a free-electron and a cavity polariton. This nonlinear interaction is faster by several orders of magnitude with respect to current photon-based cavity-QED gates, enjoys wide tunability and can demonstrate fidelities close to unity. Furthermore, our scheme is ubiquitous to any cavity nonlinearity, either due to light-matter coupling as in the Jaynes-Cummings model or due to photon-photon interactions as in a Kerr-type many-body system. In addition to promising advancements in cavity-QED quantum computation, our approach paves the way towards ultrafast and deterministic generation of highly-entangled photonic graph states and is applicable to other quantum technologies involving cavity-QED.

Diffractive optical elements (DOEs) have a wide range of applications in optics and photonics, thanks to their capability to perform complex wavefront shaping in a compact form. However, widespread applicability of DOEs is still limited, because existing fabrication methods are cumbersome and expensive. Here, we present a simple and cost-effective fabrication approach for solid, high-performance DOEs. The method is based on conjugating two nearly refractive index-matched solidifiable transparent materials. The index matching allows for extreme scaling up of the elements in the axial dimension, which enables simple fabrication of a template using commercially available 3D printing at tens-of-micrometer resolution. We demonstrated the approach by fabricating and using DOEs serving as microlens arrays, vortex plates, including for highly sensitive applications such as vector beam generation and super …