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Dec 2021 • Energy Technology

Silver Oxygen Reduction Electrocatalyst in Alkaline Medium: Aging and Protective Coating

Anna Kitayev, Melina Zysler, Samuel Hardisty, Miles Page, Ervin Tal-Gutelmacher, David Zitoun

The oxygen reduction reaction (ORR) is a key process in anion exchange membrane fuel cells. The alkaline conditions should allow silver‐based cost‐efficient catalysts to replace platinum group metal materials. However, Ag electrochemical stability or lack of stability in alkaline medium is still to be demonstrated. Herein, Ag catalyst nanoparticles (NPs) are characterized by identical location transmission electron microscopy and X‐ray photoelectron spectroscopy after electrochemical cycling, revealing the losses of activity and surface. Herein, a facile method for enhancing the chemical stability of Ag catalysts in an alkaline environment by depositing a protective polydopamine (PDA) coating is reported. It is enhanced via crosslinking with polyethyleneimine (PEI), on the surface of Ag NPs. The enhanced electrochemical stability of Ag PDA–PEI nanocatalyst via the analysis of ORR polarization curves during …

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Dec 2021 • Israel Journal of Chemistry 61 (11-12), 697-707, 2021

Nanocrystals as Model Systems for Studying the Interplay Between Crystallization and Chirality

Uri Hananel, Assaf Ben Moshe, Gil Markovich, A Paul Alivisatos

The interplay between crystallization and chirality has fascinated chemists for over 170 years now. Many questions deal with the transfer of chirality from molecular level building blocks and crystal capping ligands to the macroscopic morphologies of crystals. Also the interest in nanoscale chiral crystallization and the relationship between chiral ligands and inorganic nanocrystals has recently arose. In this review we highlight several different topics related to studies of the interplay between chirality and crystallization that involve inorganic nanocrystals. Specifically, we differentiate between the effects of chiral molecules on inorganic nanocrystals with chiral or achiral crystal structures. In the first case, chirality may appear both at the atomic‐scale and the particle shape, and in the second case chirality may be induced only at the particle shape level. We also discuss recent progress on the relationship between the …

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Dec 2021 • ACS Applied Materials & Interfaces

Selective Catalyst Surface Access through Atomic Layer Deposition

Samuel S Hardisty, Shira Frank, Melina Zysler, Reut Yemini, Anya Muzikansky, Malachi Noked, David Zitoun

Dec 2021 • Materials Science and Engineering: C

Sonochemically engineered nano-enabled zinc oxide/amylase coatings prevent the occurrence of catheter-associated urinary tract infections

Aleksandra Ivanova, Kristina Ivanova, Ilana Perelshtein, Aharon Gedanken, Katerina Todorova, Rositsa Milcheva, Petar Dimitrov, Teodora Popova, Tzanko Tzanov

Catheter-associated urinary tract infections (CAUTIs), caused by biofilms, are the most frequent health-care associated infections. Novel antibiofilm coatings are needed to increase the urinary catheters' life-span, decrease the prevalence of CAUTIs and reduce the development of antimicrobial resistance. Herein, antibacterial zinc oxide nanoparticles (ZnO NPs) were decorated with a biofilm matrix-degrading enzyme amylase (AM) and simultaneously deposited onto silicone urinary catheters in a one-step sonochemical process. The obtained nano-enabled coatings inhibited the biofilm formation of Escherichia coli and Staphylococcus aureus by 80% and 60%, respectively, for up to 7 days in vitro in a model of catheterized bladder with recirculation of artificial urine due to the complementary mode of antibacterial and antibiofilm action provided by the NPs and the enzyme. Over this period, the coatings did not induce …

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Dec 2021 • Oncotarget

Correction: The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells

Shlomit Brodie, Hae Kyung Lee, Wei Jiang, Simona Cazacu, Cunli Xiang, Laila M Poisson, Indrani Datta, Steve Kalkanis, Doron Ginsberg, Chaya Brodie

This article has been corrected: The bioinformatics analysis of TCGA data in Figure 4 (panels A, B, C, I) was inadvertently conducted on LINC00116. We have reworked that analysis using the LINC01116 expression values so that it is aligned with the rest of the paper, which discusses LINC01116. The redrawn Figures 4A-C and 4I and edits to the associated paragraph in the text are shown below. Please note that similar trends are shown for LINC00116 and LINC01116 so the primary message of the paper is not affected. The authors declare that these corrections do not change the results or conclusions of this paper.Original article: Oncotarget. 2017; 8: 31785–31801. https://doi. org/10.18632/oncotarget. 15991

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Dec 2021 • Virology journal

Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells

Coral Orel Haddad, Inna Kalt, Yehuda Shovman, Lei Xia, Yehuda Schlesinger, Ronit Sarid, Oren Parnas

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a transforming gammaherpesvirus. Like other herpesviruses, KSHV infection is for life long and there is no treatment that can cure patients from the virus. In addition, there is an urgent need to target viral genes to study their role during the infection cycle. The CRISPR-Cas9 technology offers a means to target viral genomes and thus may offer a novel strategy for viral cure as well as for better understanding of the infection process. We evaluated the suitability of this platform for the targeting of KSHV. We have used the recombinat KSHV BAC16 genome, which contains an expression cassette encoding hygromycin-resistance and a GFP marker gene. Three genes were targeted: gfp, which serves as a marker for infection; orf45 encoding a lytic viral protein; and orf73, encoding LANA which is crucial for latent infection. The fraction of cells expressing GFP, viral DNA levels and LANA expression were monitored and viral genomes were sequenced. We found that KSHV episomes can be targeted by CRISPR-Cas9. Interestingly, the quantity of KSHV DNA declined, even when target sites were not functionally important for latency. In addition, we show that antibiotic selection, used to maintain infection, interferes with the outcome of targeting. Our study provides insights into the use of this fundamental approach for the study and manipulation of KSHV. It provides guidelines for the targeting CRISPR-Cas9 to the viral genome and for outcomes interpretation.

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Nov 2021 • International Journal of Molecular Sciences

Latently KSHV-infected cells promote further establishment of latency upon superinfection with KSHV

Chen Gam ze Letova, Inna Kalt, Meir Shamay, Ronit Sarid

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a cancer-related virus which engages in two forms of infection: latent and lytic. Latent infection allows the virus to establish long-term persistent infection, whereas the lytic cycle is needed for the maintenance of the viral reservoir and for virus spread. By using recombinant KSHV viruses encoding mNeonGreen and mCherry fluorescent proteins, we show that various cell types that are latently-infected with KSHV can be superinfected, and that the new incoming viruses establish latent infection. Moreover, we show that latency establishment is enhanced in superinfected cells compared to primary infected ones. Further analysis revealed that cells that ectopically express the major latency protein of KSHV, LANA-1, prior to and during infection exhibit enhanced establishment of latency, but not cells expressing LANA-1 fragments. This observation supports the notion that the expression level of LANA-1 following infection determines the efficiency of latency establishment and avoids loss of viral genomes. These findings imply that a host can be infected with more than a single viral genome and that superinfection may support the maintenance of long-term latency.

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Nov 2021 • The Journal of Physical Chemistry C

Asymmetric Spin Transport in Colloidal Quantum Dot Junctions

John P Philbin, Amikam Levy, Prineha Narang, Wenjie Dou

The study of charge and spin transport through semiconductor quantum dots is experiencing a renaissance due to recent advances in nanofabrication and the realization of quantum dots as candidates for quantum computing. In this work, we combine atomistic electronic structure calculations with quantum master equation methods to study the transport of electrons and holes through strongly confined quantum dots coupled to two leads with a voltage bias. We find that a competition between the energy spacing between the two lowest quasi-particle energy levels and the strength of the exchange interaction determines the spin states of the lowest two quasi-particle energy levels. Specifically, the low density of electron states results in a spin singlet being the lowest-energy two-electron state, whereas, in contrast, the high density of states and significant exchange interaction result in a spin triplet being the lowest …

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Nov 2021 • JOSA B

Light detection and ranging (lidar): introduction

Zeev Zalevsky, Gerald S Buller, Tao Chen, Moshik Cohen, Rory Barton-Grimley

In this introduction we provide an overview of the papers that were accepted for publication in the special issue on light detection and ranging (lidar). Four of the papers were published in JOSA A, and four were published in JOSA B. They represent different aspects of this important and fast-growing field while showing the relevant state-of-the-art achievements currently existing in the field of lidars in the world of science and engineering.

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Nov 2021 • ACS Applied Materials & Interfaces

Evaluation of Mg[B(HFIP)4]2-Based Electrolyte Solutions for Rechargeable Mg Batteries

Ben Dlugatch, Meera Mohankumar, Ran Attias, Balasubramoniam Murali Krishna, Yuval Elias, Yosef Gofer, David Zitoun, Doron Aurbach

Nov 2021 • Energy Storage Materials

Boron doped Ni-rich LiNi0. 85Co0. 10Mn0. 05O2 cathode materials studied by structural analysis, solid state NMR, computational modeling, and electrochemical performance

Susai Francis Amalraj, Ravikumar Raman, Arup Chakraborty, Nicole Leifer, Raju Nanda, Sooraj Kunnikuruvan, Tatyana Kravchuk, Judith Grinblat, Vladimir Ezersky, Rong Sun, Francis Leonard Deepak, Christoph Erk, Xiaohan Wu, Sandipan Maiti, Hadar Sclar, Gil Goobes, Dan Thomas Major, Michael Talianker, Boris Markovsky, Doron Aurbach

This work is part of ongoing and systematic investigations by our groups on the synthesis, electrochemical behavior, structural investigations, and computational modeling of the Ni-rich materials Li[NixCoyMnz]O2 (x+y+z=1; x≥0.8) for advanced lithium-ion batteries. This study focuses on the LiNi0.85Co0.10Mn0.05O2 (NCM85) material and its improvement upon doping with B3+ cations. The data demonstrate the substantial improvement of the doped electrodes in terms of cycling performance, lower voltage hysteresis and reduced self-discharge upon high temperature storage. The electronic structure of the undoped and B-doped material was modelled using density functional theory (DFT), which identified interstitial positions as the preferential location of the dopant. DFT models were also used to shed light on the influence of boron on surface segregation, surface stability, and oxygen binding energy in NCM85 …

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Nov 2021 • Journal of the American Chemical Society

High energy density rechargeable batteries based on Li metal anodes. The role of unique surface chemistry developed in solutions containing fluorinated organic co-solvents

Doron Aurbach, Elena Markevich, Gregory Salitra

To date, lithium ion batteries are considered as a leading energy storage and conversion technology, ensuring a combination of high energy and power densities and prolonged cycle life. A critical point for elaboration of high energy density secondary Li batteries is the use of high specific capacity positive and negative electrodes. Among anode materials, Li metal anodes are considerably superior due to having the highest theoretical specific capacity (3860 mAh g–1) and lowest negative redox potential (−3.040 V vs a standard hydrogen electrode). Combination of Li metal anodes with Li[NiCoM]O2-layered cathodes with a high stable specific capacity of about 200 up to 250 mAh g–1 is particularly attractive. The development of advanced electrolyte solutions which ensure effective passivation of the electrodes’ surfaces is of critical importance. Considerable efforts have been focused on fluorinated organic co …

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Nov 2021 • ACS Sustainable Chemistry & Engineering

Phase-dependent photocatalytic activity of bulk and exfoliated defect-controlled flakes of layered copper sulfides under simulated solar light

Madina Telkhozhayeva, Rajashree Konar, Ronit Lavi, Eti Teblum, Bibhudatta Malik, Sharon Ruthstein, Elisa Moretti, Gilbert Daniel Nessim

Sunlight-driven photocatalysis is an environmentally friendly approach to solve ecological issues. The development of simple yet sufficiently stable photocatalytic materials capable of responding to the full-spectrum light remains challenging. Here, we demonstrate the phase transformations of bulk copper sulfides from digenite (Cu9S5) to djurleite (Cu1.97S) and low chalcocite (Cu2S) by the reactive thermal annealing during ambient pressure chemical vapor deposition, followed by their top-down exfoliation. Using multiple techniques, we confirm that monoclinic Cu2S is primarily formed at higher temperatures or greater reaction times and using a reducing atmosphere. We measured the average thickness to be approximately 4 nm for the exfoliated flakes with relatively large lateral sizes of up to 10 μm. We tested the three phases of bulk copper sulfides and their exfoliated forms as photocatalysts for dye degradation …

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Nov 2021 • ACS Applied Nano Materials

Polydopamine Nanoparticles Containing a Cisplatin Analog for Anticancer Treatment and Diagnostics

Gil Yeroslavsky, Michal Richman, Asaf Gertler, Haim Y Cohen, Menachem Motiei, Rachela Popovtzer, Hugo E Gottlieb, Shai Rahimipour

Cancer is a leading cause of death with rates expected to grow with life expectancy. Among leading treatments, cisplatin, widely used to combat cancer, suffers from low stability and selectivity. Here, we covalently conjugated an analog of cisplatin to biocompatible polydopamine nanoparticles (PDA-NPs) to increase both properties. Dynamic light scattering and electron microscopy studies suggest that the platinum-conjugated PDA particles (Pt–PDA-NPs) are monodispersed and spherical with a diameter of about 200 nm with platinum atoms mostly in the shell. Particles were also characterized with inductively coupled plasma mass atomic emission spectroscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy to determine the localization and amount of Pt atoms. The chelated metal did not leach from the conjugated particles under normal physiological conditions, while it was released …

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Nov 2021 • Journal of The Electrochemical Society

Toward high performance all solid-state Na batteries: investigation of electrolytes comprising NaPF6, poly (ethylene oxide) and TiO2

Gayathri Peta, Shaul Bublil, Hadas Alon-Yehezkel, Ortal Breuer, Yuval Elias, Nethanel Shpigel, Miryam Fayena-Greenstein, Diana Golodnitsky, Doron Aurbach

Solid electrolytes based on polyethylene oxide (PEO) have been studied for decades, owing to their facile and low-cost processing, good electrochemical stability, and excellent complexation with alkali metal salts. Complexes of PEO with appropriate sodium salts are well known for ionic conduction. Here, pristine NaPF 6: P (EO) 16 and a composite solid electrolyte containing TiO 2 nanowires were investigated as candidates for rechargeable solid-state sodium batteries. Comprehensive electrochemical characterizations were carried out, including ionic conductivity, transference number, and structural stability. At elevated temperatures, the specific capacity of an all-solid-state Na 3 Ti 2 (PO 4) 3 (Na/NTP) sodium battery was 110 mAh g− 1, higher than room-temperature cells with liquid electrolyte solutions. We attribute this behavior to increased conductivity of the polymer electrolyte, induced by the ceramic …

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Nov 2021 • Mbio

The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors …

Uthman Okalang, Bar Mualem Bar-Ner, K Shanmugha Rajan, Nehemya Friedman, Saurav Aryal, Katarina Egarmina, Ronen Hope, Netaly Khazanov, Hanoch Senderowitz, Assaf Alon, Deborah Fass, Shulamit Michaeli

In the parasite Trypanosoma brucei, the causative agent of human African sleeping sickness, all mRNAs are trans-spliced to generate a common 5′ exon derived from the spliced leader (SL) RNA. Perturbations of protein translocation across the endoplasmic reticulum (ER) induce the spliced leader RNA silencing (SLS) pathway. SLS activation is mediated by a serine-threonine kinase, PK3, which translocates from the cytosolic face of the ER to the nucleus, where it phosphorylates the TATA-binding protein TRF4, leading to the shutoff of SL RNA transcription, followed by induction of programmed cell death. Here, we demonstrate that SLS is also induced by depletion of the essential ER-resident chaperones BiP and calreticulin, ER oxidoreductin 1 (ERO1), and the Golgi complex-localized quiescin sulfhydryl oxidase (QSOX). Most strikingly, silencing of Rhomboid-like 1 (TIMRHOM1), involved in mitochondrial …

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Nov 2021 • Photochemical & Photobiological Sciences

Fluorophore spectroscopy in aqueous glycerol solution: the interactions of glycerol with the fluorophore

Haim Feldman, Mark A Iron, Dror Fixler, Sergei Moshkov, Naomi Zurgil, Elena Afrimzon, Mordechai Deutsch

A common perception exists that glycerol provides an inert-like environment modifying viscosity and index of refraction by its various concentrations in aqueous solution. Said perception is herein challenged by investigating the effects of the glycerol environment on the spectroscopic properties of fluorescein, as a representative fluorophore, using steady-state and time-resolved techniques and computational chemistry. Results strongly suggest that the fluorescence quantum yield, measured fluorescence lifetime (FLT), natural lifetime and calculated fluorescence lifetime are all highly sensitive to the presence of glycerol. Glycerol was found to impact both the ground and first excited states of fluorescein, quenching and modifying both absorption and emission spectra, affecting the fundamental electrical dipoles of the ground and first excited singlet states, and lowering FLT and quantum yield. Furthermore, the …

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Nov 2021 • Journal of the American Chemical Society

Tunable Cr4+ Molecular Color Centers

Daniel W Laorenza, Arailym Kairalapova, Sam L Bayliss, Tamar Goldzak, Samuel M Greene, Leah R Weiss, Pratiti Deb, Peter J Mintun, Kelsey A Collins, David D Awschalom, Timothy C Berkelbach, Danna E Freedman

The inherent atomistic precision of synthetic chemistry enables bottom-up structural control over quantum bits, or qubits, for quantum technologies. Tuning paramagnetic molecular qubits that feature optical-spin initialization and readout is a crucial step toward designing bespoke qubits for applications in quantum sensing, networking, and computing. Here, we demonstrate that the electronic structure that enables optical-spin initialization and readout for S = 1, Cr(aryl)4, where aryl = 2,4-dimethylphenyl (1), o-tolyl (2), and 2,3-dimethylphenyl (3), is readily translated into Cr(alkyl)4 compounds, where alkyl = 2,2,2-triphenylethyl (4), (trimethylsilyl)methyl (5), and cyclohexyl (6). The small ground state zero field splitting values (<5 GHz) for 1–6 allowed for coherent spin manipulation at X-band microwave frequency, enabling temperature-, concentration-, and orientation-dependent investigations of the spin dynamics …

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Nov 2021 • Journal of Lightwave Technology

Forward stimulated Brillouin scattering analysis of optical fibers coatings

Hilel Hagai Diamandi, Yosef London, Gil Bashan, Keren Shemer, Avi Zadok

The proper function of protective coating layers is essential for the handling and application of brittle optical fibers. The elastic parameters of polymer coatings can be studied through off-line analysis of test samples. However, the monitoring of these properties on a working fiber during service is challenging. In this work, we use forward stimulated Brillouin scattering processes in standard single mode fibers to measure the acoustic velocity in several types of coating layers. Pump light launches short acoustic pulses outward from the core of the fiber. Multiple reflections at the boundaries between cladding and coating, and between coating and air, form a series of delayed acoustic echoes across the core. These echoes are monitored, in turn, by photo-elastic phase modulation of probe light. Data are collected at temperatures between 25-120 °C. The thermal dependence of the acoustic velocities in several coatings …

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Nov 2021 • Batteries & Supercaps

Molecular Layer Deposition of Alucone Thin Film on LiCoO2 to Enable High Voltage Operation

Ortal Lidor‐Shalev, Nicole Leifer, Michal Ejgenberg, Hagit Aviv, Ilana Perelshtein, Gil Goobes, Malachi Noked

Extracting the theoretically high capacity of LiCoO2 (LCO) is desirable for enhancing the energy density of currently used lithium‐ion batteries (LIBs) for portable devices. The bottleneck for exhibiting the high capacity is associated with the limited cut‐off positive voltages beyond which degradation of electrode/electrolyte takes place. In this work, we apply hybrid organic‐inorganic alucone thin film grown directly on LCO by a molecular layer deposition (MLD) method, using sequential exposure to Al‐based and organic‐based precursors. The alucone thin films enabled the high voltage operation of the LCO cathode (>4.5 V), acting as a protection layer. Electrochemical studies proved that alucone coated LCO show enhanced electrochemical performances with improved cycling stability and enhanced specific capacity, relative to uncoated LCO. Amongst the studied films, 10 nm ethylene glycol/Al coated LCO have …

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Nov 2021 • JOSA B

Light detection and ranging (lidar): introduction

Zeev Zalevsky, Gerald S Buller, Tao Chen, Moshik Cohen, Rory Barton-Grimley

In this introduction we provide an overview of the papers that were accepted for publication in the special issue on light detection and ranging (lidar). Four of the papers were published in JOSA A, and four were published in JOSA B. They represent different aspects of this important and fast-growing field while showing the relevant state-of-the-art achievements currently existing in the field of lidars in the world of science and engineering.

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