May 2022 • J Clin Aesthet Dermatol
Rachel Lubart, Inbar Yariv, Dror Fixler, Anat Lipovsky
Background. Collagen protein plays a notable role maintaining firm skin. Topical creams containing collagen fibers are widely available, but their usefulness is questionable due to limited skin penetration. When applied in a cream, collagen does not penetrate the skin leaving the skin structure unaffected.Objective. We formulated micronized collagen in a cream base. Using human skin samples, we sought to investigate the ability of the micronized collagen cream to penetrate human skin. Methods. Particle sizes of micronized marine collagen were evaluated using electron microscopy. Optical profilometry was conducted to evaluate skin topography and roughness. The antioxidant activity of the collagen was evaluated using the electron paramagnetic resonance technique by measuring the changes in free radical production. Collagen penetration depth in human skin samples was monitored using a non-invasive optical technique known as iterative multiplane optical property extraction, which works based on the detection of laser light phase changes following the presence of collagen particles in deep skin layers.Results. According to the electron microscopy, collagen particles were found to be of various sizes, the smallest being about 120nm in diameter. Skin topography measurements revealed that the treated collagen cream increased skin smoothness of the samples. Our results derived from the iterative multiplane optical property extraction indicated that micronized collagen in a cream base penetrates both the stratum corneum and the deep epidermal layers toward the dermis.Conclusion. Our investigation suggests that the collagen in the …
Show moreMay 2022 • arXiv preprint arXiv:2205.08563
Hennadii Yerzhakov, Roni Ilan, Efrat Shimshoni, Jonathan Ruhman
May 2022 • The Journal of Immunology
Amit Gilboa, Ronen Hope, Shira Ben Simon, Pazit Polak, Omry Koren, Gur Yaari
The immune system matures throughout childhood to achieve full functionality in protecting our bodies against threats. The immune system has a strong reciprocal symbiosis with the host bacterial population and the two systems co-develop, shaping each other. Despite their fundamental role in health physiology, the ontogeny of these systems is poorly characterized. In this study, we investigated the development of the BCR repertoire by analyzing high-throughput sequencing of their receptors in several time points of young C57BL/6J mice. In parallel, we explored the development of the gut microbiome. We discovered that the gut IgA repertoires change from birth to adolescence, including an increase in CDR3 lengths and somatic hypermutation levels. This contrasts with the spleen IgM repertoires that remain stable and distinct from the IgA repertoires in the gut. We also discovered that large clones that germinate …
Show moreMay 2022 • Scientific Reports
Abhijit Sanjeev, Vismay Trivedi, Zeev Zalevsky
“However, this technique suffers from the fact that it requires a lot of image processing tools, and post processing”“Another interesting approach is to exploit the memory effect of speckles. Memory effect states that there exists a correlation between a speckle pattern even when the laser illumination is tilted within a given angular range. Freund12, 13 used the scattering media as a lens based on speckle intensity correlation. This idea was extended by Bertolotti et al. 14 to image a fluorescent object behind the media.” now reads:“Another interesting approach is to exploit the memory effect of speckles. Memory effect states that there exists a correlation between a speckle pattern even when the laser illumination is tilted within a given angular range. Freund12–14 used the scattering media as a lens based on speckle intensity correlation. This idea was extended by Bertolotti et al. 13 to image a fluorescent object behind …
Show moreMay 2022 • CLEO: QELS_Fundamental Science, FW5I. 7, 2022
D Beitner, I Carmeli, Z Zalevsky, S Richter, H Suchowski
Utilizing a combination of hyperspectral measurements and sorting K-means algorithms, we study coupled J-aggregate–plasmonic nanostructures system. The effect of proximity and cover ratio of the J-aggregates on the plasmonic resonance is shown and modeled.
Show moreMay 2022 • CLEO: QELS_Fundamental Science, JTh3A. 65, 2022
Xuan Zhu, Chun-Hung Chang, Carlos González-Arciniegas, Avi Pe’er, Olivier Pfister
We report on the progress of experimental cluster-state generation in the optical frequency comb of a single, phase-modulated optical parametric oscillator.
Show moreMay 2022 • CLEO: QELS_Fundamental Science, JW3B. 66, 2022
Bhupesh Kumar, Patrick Sebbah
May 2022 • Cytotherapy
A Edri, A Hailu, N Ben Haim, N Brycman, O Berhani-Zipori, J Rifman, S Cohen, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen
May 2022 • Nature Communications
Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more prone to progress to metastatic disease, with decreased survival, than those with R175 mutations. We identify a distinct transcriptional signature orchestrated by p53R273H, implicating activation of oncogenic signaling pathways and predicting worse outcome. These features are shared also with the hotspot mutants p53R248Q and p53R248W. p53R273H selectively promotes rapid CRC cell spreading, migration, invasion and metastasis. The transcriptional output of p53R273H is associated with preferential binding to regulatory elements of R273 signature genes. Thus, different TP53 missense mutations contribute differently to cancer progression. Elucidation of the …
Show moreMay 2022 • 241st ECS Meeting (May 29-June 2, 2022)
Hilah Clara Honig, Lior Elbaz
May 2022 • 241st ECS Meeting (May 29-June 2, 2022)
Wenjamin Moschkowitsch, Lior Elbaz
May 2022 • Beilstein Archives
Shani Zev, Marion Ringel, Ronja Driller, Bernhard Loll, Thomas Brück, Dan T Major
Terpene synthases are responsible for the biosynthesis of terpenes, the largest family of natural products. Hydropyrene synthase generates hydropyrene and hydropyrenol as its main products along with two byproducts, isoelisabethatriene A and B. Fascinatingly, a single active site mutation (M75L) diverts the product distribution towards isoelisabethatriene A and B. In the current work, we study the competing pathways leading to these products using quantum chemical calculations in the gas-phase. We show that there is a great thermodynamic preference for hydropyrene and hydropyrenol formation, and hence most likely in the synthesis of the isoelisabethatriene products kinetic control is at play.
Show moreMay 2022 • arXiv preprint arXiv:2205.09677
Aditya Chandra Mandal, Abhijeet Phatak, Zeev Zalevsky, Rakesh Kumar Singh
The wavefront is scrambled when coherent light propagates through a random scattering medium and which makes direct use of the conventional optical methods ineffective. In this paper, we propose and demonstrate a structured light illumination for imaging through an opaque scattering layer. Proposed technique is reference free and capable to recover the complex field from intensities of the speckle patterns. This is realized by making use of the phase-shifting in the structured light illumination and applying spatial averaging of the speckle pattern in the intensity correlation measurement. An experimental design is presented and simulated results based on the experimental design are shown to demonstrate imaging of different complex-valued objects through scattering layer.
Show moreMay 2022 • CLEO: QELS_Fundamental Science, JTu3B. 6, 2022
Y Piasetzky, M Katzman, M Priel, H Suchowski, A Zadok
We demonstrate a high-fidelity directional coupler in photonic integrated waveguides, utilizing a novel scheme of detuning modulated composite segments. We reduce the wavelength dependence by almost an order of magnitude, indicating significantly increased robustness.
Show moreMay 2022 • Cytotherapy
J Rifman, N Ben Haim, S Cohen, N Brycman, A Hailu, O Berhani-Zipori, A Edri, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen
May 2022 • ANESTHESIA AND ANALGESIA 134, 536-537, 2022
Donald H Penning, Simona Cazacu, Rephael Nizar, Chaya Brodie
May 2022 • CLEO: Science and Innovations, JTh3A. 15, 2022
Kavita Sharma, Elad Zehavi, H Hagai Diamandi, Gil Bashan, Yosef London, Avi Zadok
Direct, distributed analysis of forward scattering is demonstrated for the first time in any optical medium, using inter-modal nonlinear coupling in polarization maintaining fibers. Local spectra of forward Brillouin scattering and Kerr effect are resolved.
Show moreMay 2022 • 2022 Conference on Lasers and Electro-Optics (CLEO), 1-2, 2022
Maya Yevnin, Eyal Cohen, Tomer Yanir, Zeev Zalevsky
We present a fiber-based photonic computing concept and system which rely on incoherent data encoding and scalable architecture. Our results suggest projected performance of> 1,000,000 Tera operations per second (TOPs) and efficiency of> 1000 TOPs/Watt.
Show moreMay 2022 • ChemPlusChem
Bibhudatta Malik, Sumit Majumder, Roberto Lorenzi, Ilana Perelshtein, Michal Ejgenberg, Alberto Paleari, Gilbert Daniel Nessim
Tailoring the precise construction of non‐precious metals and carbon‐based heterogeneous catalysts for electrochemical oxygen evolution reaction (OER) and methanol oxidation reaction (MOR) is crucial for energy conversion applications. Herein, this work reports the composite of Ni doped Fe2O3 (Ni−Fe2O3) with mildly oxidized multi‐walled CNT (O−CNT) as an outstanding Mott‐Schottky catalyst for OER and MOR. O−CNT acts as a co‐catalyst which effectively regulates the charge transfer in Ni−Fe2O3 and thus enhances the electrocatalytic performance. Ni−Fe2O3/O−CNT exhibits a low onset potential of 260 mV and overpotential 310 mV @ 10 mA cm−2 for oxygen evolution. Being a Mott‐Schottky catalyst, it achieves the higher flat band potential of −1.15 V with the carrier density of 0.173×1024 cm−3. Further, in presence of 1 M CH3OH, it delivers the MOR current density of 10 mA cm−2 at 1.46 V …
Show moreMay 2022 • Micro-Structured and Specialty Optical Fibres VII 12140, 62-66, 2022
Shlomi Zilberman, Yosef London, Alon Bernstein, Kavita Sharma, Hilel H Diamandi, Mirit Hen, Elad Zehavi, Gil Bashan, Garry Berkovic, Amnon Zentner, Moshe Mayoni, Ehud Shafir, Avi Zadok
In this work, we demonstrate optomechanical measurements of radiation induced alterations of the acoustic velocity in a fluoroacrylate polymer coating of a silica optical fiber. The optomechanical measurement is based on forward Brillouin scattering initiated in the fiber core which stimulates acoustic waves that reach the fiber coating. The measurement may serve as an additional metric to quantify the dose of ionizing radiation to which the fiber was exposed. We have demonstrated that the stiffness of the coating increases following gamma irradiation, as measured by the time of flight of radial acoustic waves through the coating. The measurement was performed on few meters long fiber, but can be extended to a spatially distributed analysis in longer fibers. The tests showed a linear dependence of the acoustic time-of flight on the overall dosage of gamma irradiation. The time of flight decreased by as much as 15 …
Show moreMay 2022 • Optics Express
Mark Golberg, Ran Califa, Sagi Polani, Orit Goldstein, Zailer Aviram, Meir Niska, Zeev Zalevsky
Diabetic foot is a well-known problem among patients suffering from peripheral arterial diseases (PAD). This article presents an optical sensor for contactless measurement of the anatomical site based on laser speckle techniques. The sensor illuminates the inspected tissue and analyzes the captured back-reflected light from the time-changing speckle patterns. An occlusion test was implemented to provide a statistical parameter to differentiate between a low perfused and a healthy foot. A clinical study of 15 subjects was conducted. The video was analyzed by two methods: dynamic laser speckle (DLS) and laser speckle contrast analysis (LASCA). Data analysis included several classification models, where the KNN model exhibited maximum performance. These findings suggest that a simple and inexpensive system for PAD monitoring can be designed for home use and/or in community clinics.
Show more