BINA

All‐solid‐state lithium batteries (ASSLBs) are considered as an alternative solution to lithium‐ion batteries, because of their safety and high theoretical energy density. Argyrodite‐based solid‐electrolytes (SEs), Li6PS5X (X = Cl, Cl0.5Br0.5 or Br), are promising candidates for ASSLBs. Most of the previous reports have used Li6PS5Cl as the default SE composition. Here, the electrochemical behavior of three different argyrodites with Cl− or Br−, or both, as the halogen is systematically studied. Using LiNi0.6Co0.2Mn0.2O2 as a model cathode, the behavior of these SEs in ASSLB cells is also studied. SEs containing Br show higher near‐room‐temperature ionic conductivity (>2 mS cm−1) and the critical current density (≥1 mA cm−2) during Li plating/stripping, and are stable up to 5 V versus Li/Li+. Li6PS5Br gives the best electrochemical performance in terms of C‐rate and long‐term cycling among the three …

Cisplatin (CP) is the rst-line standard of care for bladder cancer. However, a signi cant percentage of advanced bladder cancer patients are ineligible to receive standard CP treatment, due to the drug’s toxicity, and in particular its nephrotoxicity. These patients currently face suboptimal therapeutic options with lower e cacy. To overcome this limitation, here we designed CP-conjugated gold nanoparticles (GNPs) with speci c properties that prevent renal toxicity, and concurrently preserve the therapeutic e cacy of CP. Safety and e cacy of the particles were studied in bladder tumor-bearing mice, using clinically-relevant fractionated or non-fractionated dosing regimens. A non-fractionated high dose of CPGNP showed long-term intratumoral accumulation, blocked tumor growth, and nulli ed the lethal effect of CP. Treatment with fractionated lower doses of CP-GNP was also superior to an equivalent treatment with free CP, demonstrating both anti-tumor e cacy and prolonged mouse survival. Moreover, as opposed to free drug, CP-conjugated GNPs did not cause brosis or necrosis in kidney. These results indicate that conjugating CP to GNPs can serve as an effective, combined anti-cancer and renoprotective approach, and thus has potential to widen the range of patients eligible for CP-based therapy.

Temporal optics, and specifically time-lenses and time-stretch systems, revolutionized the field of ultrafast measurements. Over the last years, we utilized time-lenses to measure different quantum schemes and studied the temporal modes of correlated photons with high temporal resolution. We developed temporal schemes based on quantum light, for realizing quantum tomography in the time-domain. We developed low-resolution time-lenses for weak quantum measurements. Finally, we suggest how quantum time-lens can lead to optical deep learning systems. In the talk, I will give an overview of the different types of quantum temporal schemes, elaborate on the future challenges in the field, and discuss the prospects and future applications which may be possible.

A novel technology for the precise fabrication of quartz resonators for MEMS applications is introduced. This approach is based on the laser-induced chemical etching of quartz. The main processing steps include femtosecond UV laser treatment of a Cr-Au-coated Z-cut alpha quartz wafer, followed by wet etching. The laser-patterned Cr-Au coating serves as an etch mask and is used to form electrodes for piezoelectric actuation. This fabrication approach does not alter the quartz’s crystalline structure or its piezo-electric properties. The formation of defects, which is common in laser micromachined quartz, is prevented by optimized process parameters and by controlling the temporal behavior of the laser-matter interactions. The process does not involve any lithography and allows for high geometric design flexibility. Several configurations of piezoelectrically actuated beam-type resonators were fabricated using …

The Aharonov-Bohm (AB) effect has been highly influential in fundamental and applied physics. Its topological nature commonly implies that an electron encircling a magnetic flux source in a field-free region must close the loop in order to generate an observable effect. In this Letter, we study a variant of the AB effect that apparently challenges this concept. The significance of weak values and nonlocal equations of motion is discussed as part of the analysis, shedding light on and connecting all these fundamental concepts.

The synchronization of human networks, and the possibility of obtaining an agreement in a group, are essential for our survival. The dynamics of human networks are affecting every aspect of our lives in politics, economics, science, and engineering, and are essential for our mental and physical health. We study the unique properties of human networks and their dynamics by resorting to coupled violin players. We found that the human ability to ignore inputs or to focus on an input change dramatically the dynamics of the network compared to other coupled networks. We show how human networks react to frustrating situations, how they change the network connectivity or the network coupling strength, and how they escape local minima. In addition, the formation of leaders has a significant impact on the dynamics of human groups and networks and can completely shift the trajectory of a society. We study how …

A deep learning network requires high-performance computer systems for solving complex problems with millions of parameters. In our lab, we develop a fully optical machine learning system that is based on the nonlinear four wave mixing process in multimode fibers. We exploit the optical nonlinear interactions between waves for developing a deep learning system faster than electronic based systems. finally, we resort to quantum light for realizing quantum deep learning system, which can bring the deep learning techniques to the quantum field. In this talk, we will present details of our novel system and discuss our preliminary results.

We propose and demonstrate a holographic imaging scheme exploiting random illuminations for recording hologram and then applying numerical reconstruction and twin removal. We use an in-line holographic geometry to record the hologram in terms of the second-order correlation and apply the numerical approach to reconstruct the recorded hologram. The twin image issue of the in-line holographic scheme is resolved by an unsupervised deep learning(DL) based method using an auto-encoder scheme. This strategy helps to reconstruct high-quality quantitative images in comparison to the conventional holography where the hologram is recorded in the intensity rather than the second-order intensity correlation. Experimental results are presented for two objects, and a comparison of the reconstruction quality is given between the conventional inline holography and the one obtained with the proposed technique.

Fluorescence‐based imaging has an enormous impact on our understanding of biological systems. However, in vivo fluorescence imaging is greatly influenced by tissue scattering. A better understanding of this dependance can improve the potential of non‐invasive in vivo fluorescence imaging. In this paper we present a diffusion model, based on an existing master‐slave model, of isotropic point sources imbedded in a scattering slab, representing fluorophores within a tissue. The model was compared to Monte Carlo simulations and measurements of a fluorescent slide measured through tissue‐like phantoms with different reduced scattering coefficients (0.5 to 2.5mm‐1) and thicknesses(0.5 to 5mm). Results show a good correlation between our suggested theory, simulations and experiments; while the fluorescence intensity decays as the slab's scattering and thickness increase, the decay rate decreases as the …

Severe combined immunodeficiency (SCID) is a group of disorders caused by mutations in genes involved in the process of lymphocyte maturation and function. CRISPR-Cas9 gene editing of the patient’s own hematopoietic stem and progenitor cells (HSPCs) ex vivo could provide a therapeutic alternative to allogeneic hematopoietic stem cell transplantation, the current gold standard for treatment of SCID. To eliminate the need for scarce patient samples, we engineered genotypes in healthy donor (HD)-derived CD34+ HSPCs using CRISPR-Cas9/rAAV6 gene-editing, to model both SCID and the therapeutic outcomes of gene-editing therapies for SCID via multiplexed homology-directed repair (HDR). First, we developed a SCID disease model via biallelic knockout of genes critical to the development of lymphocytes; and second, we established a knockin/knockout strategy to develop a proof-of-concept single …

Entanglement phase transitions have attracted immense attention in recent years, especially in the context of monitored quantum circuits. In such systems, the dynamics due to unitary evolution competes with the localizing effects of measurements. The phase transition of a quantum system between a trivial volume-law phase of entanglement entropy–in case of weak monitoring, into a quantum Zeno-like phase for frequent and/or strong measurements where the entanglement entropy obeys area-law, is well known in many integrable models with unitary dynamics. However recently a critical phase with a logarithmic scaling of the entanglement entropy in a class of integrable models has been identified, in the presence of dissipation.We explore such a critical transition in a monitored one-dimensional quantum spin chain, the transverse field Ising model (TFIM), in presence of integrability-breaking field and dissipation …

Fluorescence‐based imaging has an enormous impact on our understanding of biological systems. However, in vivo fluorescence imaging is greatly influenced by tissue scattering. A better understanding of this dependance can improve the potential of non‐invasive in vivo fluorescence imaging. In this paper we present a diffusion model, based on an existing master‐slave model, of isotropic point sources imbedded in a scattering slab, representing fluorophores within a tissue. The model was compared to Monte Carlo simulations and measurements of a fluorescent slide measured through tissue‐like phantoms with different reduced scattering coefficients (0.5 to 2.5mm‐1) and thicknesses(0.5 to 5mm). Results show a good correlation between our suggested theory, simulations and experiments; while the fluorescence intensity decays as the slab's scattering and thickness increase, the decay rate decreases as the …

A19. 00006: Phase Diagram of the ν= 2 quantum Hall phase in bilayer graphene*

Sending an ultrafast pulse in multimode fiber can lead to nonlinear interactions between the modes. When sending such a pulse in graded-index fibers there are cases where all the energy is transferring from the high-order modes into the lowest one. This effect is called modal self-cleaning. We developed a multimode time-lens, which measures the temporal and spatial dynamics of ultrafast signals in multimode fibers. With our system, we can detect the dynamics of each mode in time with high temporal resolution, and identify which mode is coupled to which and how the energy transfers between them. In this talk, We will present our measurement system in details and describe our novel results on modal self-cleaning. We will also comment on other multimode effects which our system can measure for the first time.

In many industrial settings, films of polymers such as polypropylene (PP) and polyethylene terephthalate (PET) require surface treatment due to poor wettability and low surface energy. Here, a simple process is presented to prepare durable thin coatings composed of polystyrene (PS) core, PS/SiO2 core–shell, and hollow SiO2 micro/nanoparticles onto PP and PET films as a platform for various potential applications. Corona-treated films were coated with a monolayer of PS microparticles by in situ dispersion polymerization of styrene in ethanol/2-methoxy ethanol with polyvinylpyrrolidone as stabilizer. A similar process on untreated polymeric films did not yield a coating. PS/SiO2 core–shell coated microparticles were produced by in situ polymerization of Si(OEt)4 in ethanol/water onto a PS-coated film, creating a raspberry-like morphology with a hierarchical structure. Hollow porous SiO2-coated microparticles onto …

Quantum interferometers are able to improve the sensitivity of classical interferometers beyond the shot-noise limit. This is done by employing squeezed states of light and destructive interference of the noise in the system. We developed a quantum SU(1,1) interferometer in the time domain. Our nonlinear quantum interferometer creates interference of the input signals at different times and frequencies. We can control the time and frequency differences for investigating the full temporal and spectral structure of the signal. This quantum interferometer can be utilized for sensing ultrafast phase changes, quantum imaging, temporal mode encoding, and studying the temporal structure of entangled photons.

Imaging systems, including human vision, have a limited capability to separate spatial features, and these can also only be extracted over a limited depth range. The limits are related to the effect of diffraction and caused by the finite dimensions of the imaging optics and the geometry of the sensor. In my talk I will present novel photonic approaches to exceed the normal resolution and depth of focus limitations and show how those concepts can be applied in practical applications such as in microscopy, biomedical sensing, and ophthalmic devices to correct visual deficiencies.

In fluorescence-based biosensing applications, to increase optical detection sensitivity, time-resolved measurements are extensively used. Magnetic modulation biosensing (MMB) is a novel, fast, and sensitive detection technology for various applications. While this technology provides high sensitivity detection of biomarkers, to date, only the time resolved signal was analyzed. Here, we use for the first time both time-resolved and spatial-resolved measurements and show that this combination drastically improves the sensitivity of an MMB-based assay.

Although single point time-resolved fluorescence anisotropy (FA) measurements are well established and routinely used for various applications in many laboratories, only a few reports described their extension into two-dimensional (2D) time-resolved FA imaging (TR-FAIM). The ability to perform TR-FAIM can offer cellular imaging based on the rotational correlation time (θ) that depends on the viscosity and dynamic properties of the tissues. We extended existing frequency domain (FD) fluorescence lifetime (FLT) imaging microscopy (FLIM) to FD TR-FAIM, which produces visual maps of θ. The proof of concept of the FD TR-FAIM was validated on 7 fluorescein solutions with increasing viscosities (achieved by increasing glycerol concentration between 0-80%). The studies were performed using images of θ as well as by characterizing the peak (mode) and the full width half maximum (FWHM) of its histograms (of …

In nanophotonic, small mode volumes, narrow resonance linewidths and field enhancements, fundamentally scales with refractive index values and are key for many implementations involving light-matter interactions. Topological insulators (TI) are a class of insulating materials that host topologically protected surface states, some of which exhibit very high permittivity values. In this talk, I will discuss our latest results on Bi2Te3 and Bi2Se3 TI nanostructures. Using polarized far-field and near field nanospectroscopy we reveal that Bi2Se3 nanobeams exhibit mid-infrared resonant modes with 2π phase shifts across the resonance. We further demonstrate that Bi2Te3 metasurfaces exhibit deep subwavelength resonant modes utilizing their record high index value peaking at n~11.

SwissSPAD3 is the latest of a family of widefield time-gated SPAD imagers developed for fluorescence lifetime imaging (FLI) applications. Its distinctive features are (i) the ability to define shorter gates than its predecessors (width W < 1 ns), (ii) support for laser repetition rates up to at least 80 MHz and (iii) a dual-gate architecture providing an effective duty cycle of 100%. We present widefield macroscopic FLI measurements of short lifetime NIR dyes, analyzed using the phasor approach. The results are compared with those previously obtained with SwissSPAD2 and to theoretical predictions.