2024 • ChemElectroChem
Shalev Blanga, Sri Harsha Akella, Merav Tsubery, Melina Zysler, Sarah Taragin, Malachi Noked
Nickel‐rich cathode materials such as LiNi0.9Co0.05Mn0.05O2 (NMC90) have gained attention due to their ability to deliver high energy densities while being cost‐effective for Lithium‐ion battery manufacturing. However, NMC90 cathodes suffer irreversible parasitic reactions such as electrolyte decomposition, severe capacity fading and impedance build‐up upon prolonged cycling. Herein, we synthesize a conformal ultrathin, surface protection layer on NMC90 powder using ZnxOy via atomic layer deposition technique (ZnxOy@NMC90). Prolonged electrochemical investigation of full cells at high discharge rates of 2 C shows that ZnxOy@NMC90 cells yielded ~31 % improvement in discharge capacity compared to pristine NMC90. Furthermore, operando electrochemical mass spectroscopy studies show that the ZnxOy@NMC90 cells have significantly suppressed electrolyte decomposition as compared to …
Show more2024 • Journal of Materials Chemistry A
Sankalpita Chakrabarty, Javeed Ahmad Dar, Akanksha Joshi, Arad Paperni, Sarah Taragin, Ananya Maddegalla, Gopalakrishnan Sai Gautam, Ayan Mukherjee, Malachi Noked
Tunnel type Na0.44MnO2 (tt-NMO) is a promising cathode for sodium-ion batteries having excellent structural stability, diffusion kinetics, and low cost. However, this cathode is reported to suffer from low initial charge capacity (e.g. ≤60 mA h g-1) due to limited accessibility of sodium ion extraction (0.22 ̶ 0.24 Na+ per formula unit) from the structure which hinders the practical viability of this material in a full battery cell. In this study, we report a tailored tt-NMO structure, synthesized using a two-step facile and scalable process, with >95% yield. Our tt-NMO demonstrated a 1st charge capacity of 110 A h g-1 followed by a 115 mA h g-1 discharge capacity within the potential window of 4 ̶ 1.7V versus Na/Na+. The long-term cycling performance at 0.5C rate and 1C rate (1C = 120 mA h g-1) shows excellent structural integrity for over 400 cycles with >75% capacity retention. We show experimentally and support it by …
Show more2024 • Proc. of SPIE Vol
Valery V Tuchin, Walter C Blondel, Zeev Zalevsky
Tissue Optics and Photonics III Page 1 PROCEEDINGS OF SPIE Volume 13010 Proceedings of SPIE 0277-786X, V. 13010 SPIE is an international society advancing an interdisciplinary approach to the science and application of light. Tissue Optics and Photonics III Valery V. Tuchin Walter C. Blondel Zeev Zalevsky Editors 9–11 April 2024 Strasbourg, France Sponsored by SPIE Cooperating Organisations Photonics 21 (Germany) EOS—European Optical Society (Germany) Published by SPIE Tissue Optics and Photonics III, edited by Valery V. Tuchin, Walter CPM Blondel, Zeev Zalevsky, Proc. of SPIE Vol. 13010, 1301001 · © 2024 SPIE 0277-786X · doi: 10.1117/12.3037614 Proc. of SPIE Vol. 13010 1301001-1 Page 2 The papers in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some …
Show more2024 • Journal of Physics: Energy
M Rosa Palacin, Patrik Johansson, Robert Dominko, Ben Dlugatch, Doron Aurbach, Zhenyou Li, Maximilian Fichtner, Olivera Lužanin, Jan Bitenc, Zhixuan Wei, Clarissa Glaser, Jürgen Janek, Ana Fernández-Barquín, Aroa R Mainar, Olatz Leonet, Idoia Urdampilleta, J Alberto Blázquez, Deyana S Tchitchekova, Alexandre Ponrouch, Pieremanuele Canepa, Gopalakrishnan Sai Gautam, Raúl San Román Gallego Casilda, Cynthia S Martinez-Cisneros, Nieves Ureña Torres, Alejandro Varez, Jean-Yves Sanchez, Kostiantyn V Kravchyk, Maksym V Kovalenko, Anastasia A Teck, Huw Shiel, Ifan EL Stephens, Mary P Ryan, Eugen Zemlyanushin, Sonia Dsoke, Rebecca Grieco, Nagaraj Patil, Rebeca Marcilla, Xuan Gao, Claire J Carmalt, Guanjie He, Maria-Magdalena Titirici
Battery technologies based in multivalent charge carriers with ideally two or three electrons transferred per ion exchanged between the electrodes have large promises in raw performance numbers, most often expressed as high energy density, and are also ideally based on raw materials that are widely abundant and less expensive. Yet, these are still globally in their infancy, with some concepts (e.g., Mg metal) being more technologically mature. The challenges to address are derived on one side from the highly polarizing nature of multivalent ions when compared to single valent concepts such as Li+ or Na+ present in Li-ion or Na-ion batteries, and on the other, from the difficulties in achieving efficient metal plating/stripping (which remains the holy grail for lithium). Nonetheless, research performed to date has given some fruits and a clearer view of the challenges ahead. These include technological topics …
Show more2024 • Advanced NanoBiomed Research, 2300130, 2024
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng
Malaria is a major public health concern with over 200 million new cases annually, resulting in significant financial costs. Preventive measures and diagnostic remedies are crucial in saving lives from malaria, and especially in developing nations. 2D materials are, therefore, ideal for fighting such an epidemic. Graphene and its derivatives are extensively studied due to their exceptional properties in this case. The biomedical applications of graphene‐based nanomaterials have gained significant interest in recent years due to their remarkable biocompatibility, solubility, and selectivity. Their unique physicochemical characteristics, like ample surface area, biofunctionality, high purity, solubility, substantial drug‐loading capacity, and superior ability to penetrate cell membranes, make them up‐and‐coming candidates as biodelivery carriers. In this review, crucial graphene‐based technologies to combat malaria are …
Show more2024 • bioRxiv
Galit Shohat-Ophir
A-to-I RNA editing is an important cellular process that modifies genomically encoded information during transcription, to generate various RNA isoforms from a single DNA sequence. It involves the conversion of specific adenosines in the RNA sequence to inosines by ADAR proteins, resulting in their recognition as guanosines by cellular machinery, and as such plays a vital role in neuronal and immune functions. Given the widespread occurrence of A-to-I RNA editing events across the animal kingdom, with thousands to millions of editing sites found in the transcriptomes of organisms such as flies and humans, identifying the critical sites and understanding their in-vivo functions remains a challenging task. Here we show for the first time the physiological importance of a single editing site, found within the extracellular domain of the glutamate-gated chloride channel (GluClα), and bridge the gap between its evolutionary conservation across Drosophila species and its function in shaping the behavior of adult flies. We used genomic editing to ablate editing at this specific site, such that the endogenous channel harbors only the unedited version and used a battery of behavioral paradigms to analyze the effects on various features of adult behavior. We provide evidence that GluClαunedited flies exhibit reduced olfactory responses to both appetitive and aversive odors, as well as impaired pheromone-dependent social interactions, and that editing of this site is required for proper processing of olfactory information in olfactory projection neurons. Our findings demonstrate that evolutionary conservation is a useful criterion to pinpoint which of the many …
Show more2024 • Advanced Optical Materials
Sukanta Nandi, Tamir Shimoni, Eyal Yitzchaik, Tomer Lewi
Lead chalcogenides are compelling materials for nanophotonics and optoelectronics due to their high refractive indices, extreme thermo‐optic coefficients, and high transparency in the mid‐infrared (MIR). In this study, PbTe hoppercubes (HC, face‐open box cubes) are synthesized and explored for their MIR resonant characteristics. Single‐particle microspectroscopy uncovered deep‐subwavelength light localization, with a spectral response dominated by both fundamental and multiple high‐order Mie‐resonant modes. Nanoimaging mapping using scattering‐type scanning near‐field optical microscopy (s‐SNOM) reveals that the scattering at the center of the HC is reduced by more than five times compared to the edges. 2D‐Hyperspectral scans conducted using a low‐power broadband MIR source and nanometer spatial resolutions provided information on the local amplitude and phase‐resolved near‐fields …
Show more2024 • EPJ Web of Conferences
Kaitlin Szederkenyi, Carine Julien, Bruno Lagarde, Ilya Olevsko, Adi Salomon, Martin Oheim
Simultaneous field- and aperture-plane (back-focal plane, BFP) imaging enriches the information content of fluorescence microscopy. In addition to the usual density and concentration maps of sample-plane images, BFP images provide information on the surface proximity and orientation of molecular fluorophores. They also give access to the refractive index of the fluorophore-embedding medium. However, in the high-NA, wide-field detection geometry commonly used in single-molecule localisation microscopies, such measurements are averaged over all fluorophores present in the objective’s field of view, thus limiting spatial resolution and specificity. We here solve this problem and demonstrate how an oblique, variable-angle, coherent ring illumination can be used to generate a Bessel beam that - for supercritical excitation angles - produces an evanescent needle of light. Scanning the sample through the this …
Show more2024 • Journal of Materials Chemistry A
Efrat Shawat Avraham, Bibhudatta Malik, Alina Yarmolenko, Rajashree Konar, Sergei Remennik, Gili Cohen Taguri, Sandro Zorzi, Elti Cattaruzza, Michael Yakov Hubner, Gilbert Daniel Nessim
Correction for ‘High performance, binder-free electrodes with single atom catalysts on doped nanocarbons for electrochemical water splitting synthesized using one-step thermally controlled delamination of thin films’ by Efrat Shawat Avraham et al., J. Mater. Chem. A, 2024, https://doi.org/10.1039/D4TA04701J.
Show more2024 • JAMA pediatrics
Ido Somekh, Ayal Hendel, Raz Somech
Inborn errors of immunity comprise more than 500 monogenic defects that predispose affected individuals to life-threatening infections, autoimmunity, and lymphoproliferation. The diagnosis and treatment of inborn errors of immunity have significantly evolved in the past few decades. 1 Currently, a hematopoietic stem cell transplant (HSCT) is the definitive treatment of many IEIs. However, an HSCT carries risks, such as graft-vshost disease and decreased survival rates in the absence of an HLA-matched donor. Gene therapy (GT) offers a promising alternative by targeting and correcting specific genetic mutations. Ex vivo GT entails geneticallymodifyingcells, typicallyCD34+ hematopoieticstem and progenitor cells (HSPCs), outside the body and then transplanting the cells back into patients, whereas in vivo GT delivers genetic material directly to target cells within the body.Corrected stem cells then regenerate and …
Show moreDec 2023 • ACS Omega
Michal Roth, Yoni Toker, Dan T Major
Understanding the physical underpinnings and geometry of molecular clusters is of great importance in many fields, ranging from studying the beginning of the universe to the formation of atmospheric particles. To this end, several approaches have been suggested, yet identifying the most stable cluster geometry (i.e., global potential energy minimum) remains a challenge, especially for highly symmetric clusters. Here, we suggest a new funneled Monte Carlo-based simulated annealing (SA) approach, which includes two key steps: generation of symmetrical clusters and classification of the clusters according to their geometry using machine learning (MCSA-ML). We demonstrate the merits of the MCSA-ML method in comparison to other approaches on several Lennard-Jones (LJ) clusters and four molecular clusters─Ser8(Cl–)2, H+(H2O)6, Ag+(CO2)8, and Bet4Cl–. For the latter of these clusters, the correct …
Show moreDec 2023 • Journal of Biological Engineering
Gal Shpun, Nairouz Farah, Yoav Chemla, Amos Markus, Tamar Azrad Leibovitch, Erel Lasnoy, Doron Gerber, Zeev Zalevsky, Yossi Mandel
Tissue-integrated micro-electronic devices for neural stimulation hold great potential in restoring the functionality of degenerated organs, specifically, retinal prostheses, which are aimed at vision restoration. The fabrication process of 3D polymer-metal devices with high resolution and a high aspect-ratio (AR) is very complex and faces many challenges that impair its functionality. Here we describe the optimization of the fabrication process of a bio-functionalized 3D high-resolution 1mm circular subretinal implant composed of SU-8 polymer integrated with dense gold microelectrodes (23μm pitch) passivated with 3D micro-well-like structures (20μm diameter, 3μm resolution). The main challenges were overcome by step-by-step planning and optimization while utilizing a two-step bi-layer lift-off process; bio-functionalization was carried out by N2 plasma treatment and the addition of a bio-adhesion molecule. In-vitro and in-vivo investigations, including SEM and FIB cross section examinations, revealed a good structural design, as well as a good long-term integration of the device in the rat sub-retinal space and cell migration into the wells. Moreover, the feasibility of subretinal neural stimulation using the fabricated device was demonstrated in-vitro by electrical activation of rat’s retina. The reported process and optimization steps described here in detail can aid in designing and fabricating retinal prosthetic devices or similar neural implants.
Show moreDec 2023 • Electrocatalysis for Membrane Fuel Cells: Methods, Modeling and Applications …, 2023
Naomi Levy, Lior Elbaz
The state‐of‐the‐art Platinum group metal (PGM)‐free oxygen reduction reaction (ORR) catalysts have been synthesized using the pyrolysis of iron, nitrogen, and carbon precursors, and result in highly active ORR catalysts, but their undefined structure limits their further development. Since the inspiration for these catalysts came from well‐defined structures of transition metal complexes, it is important to understand the various parameters that govern the reaction potential, selectivity, and the stability with well‐defined catalysts and try to extrapolate them to the pyrolyzed catalysts. In this chapter, we give an overview of the parameters that influence the catalysis of ORR with well‐defined ORR catalysts. These can later be used to further enhance the performance of the state‐of‐the‐art PGM‐free ORR catalysts.
Show moreDec 2023 • Trends in Genetics, 2023
Erez Y Levanon, Roni Cohen-Fultheim, Eli Eisenberg
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.
Show moreDec 2023 • Electrochimica Acta
Akanksha Gupta, Hari Krishna Sadhanala, Aharon Gedanken
The seawater electrolysis is an economically favorable approach for water splitting application because seawater is one of the plentiful abundant natural resources on our earth. In water splitting pathway, the anodic half-cell reaction from seawater stills a challenging task due to anodic corrosion and the competitive chloride oxidation process. In the current study, we prepared flower-shaped porous nanorods of iron doped cobalt nickel layered double hydroxide supported on nickel foam (Fe0.05 CoNi LDH/NF), which require very less oxygen evolution reaction (OER) overpotential in 1M KOH (212mV) and alkaline seawater (287mV) to deliver 10 mAcm−2 current density and exhibited remarkable 14h durability. At the same time, post treated sample reveals the better OER activity after chronopotentiometry analysis, because of superior conductivity and corrosion-resistance of the electrocatalyst. The doping of Fe cation …
Show moreDec 2023 • Angewandte Chemie 135 (50), e202306904, 2023
Amey Nimkar, Gil Bergman, Elad Ballas, Nophar Tubul, Noam Levi, Fyodor Malchik, Idan Kukurayeve, Munseok S Chae, Daniel Sharon, Mikhael Levi, Netanel Shpigel, Guoxiu Wang, Doron Aurbach
The exploration of cathode and anode materials that enable reversible storage of mono and multivalent cations has driven extensive research on organic compounds. In this regard, polyimide (PI)‐based electrodes have emerged as a promising avenue for the development of post‐lithium energy storage systems. This review article provides a comprehensive summary of the syntheses, characterizations, and applications of PI compounds as electrode materials capable of hosting a wide range of cations. Furthermore, the review also delves into the advancements in PI based solid state batteries, PI‐based separators, current collectors, and their effectiveness as polymeric binders. By highlighting the key findings in these areas, this review aims at contributing to the understanding and advancement of PI‐based structures paving the way for the next generation of energy storage systems.
Show moreDec 2023 • Nature Communications
Marlon S Zambrano-Mila, Monika Witzenberger, Zohar Rosenwasser, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Y Levanon, Schraga Schwartz
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes. We monitor how secondary structure modulates ADAR2 vs ADAR1 substrate selectivity, on the basis of systematic probing of thousands of synthetic sequences transfected into cell lines expressing exclusively ADAR1 or ADAR2. Both enzymes induce symmetric, strand-specific editing, yet with distinct offsets with respect to structural disruptions: −26 nt for ADAR2 and −35 nt for ADAR1. We unravel the basis for these differences in offsets through mutants, domain-swaps, and ADAR homologs, and find it to be encoded by the differential RNA binding domain (RBD) architecture. Finally, we demonstrate that this offset-enhanced editing can allow an improved design of ADAR2 …
Show moreDec 2023 • NAR Genomics and Bioinformatics
Rona Merdler-Rabinowicz, David Gorelik, Jiwoon Park, Cem Meydan, Jonathan Foox, Miriam Karmon, Hillel S Roth, Roni Cohen-Fultheim, Galit Shohat-Ophir, Eli Eisenberg, Eytan Ruppin, Christopher E Mason, Erez Y Levanon
Dec 2023 • arXiv preprint arXiv:2312.10367
Yaron Hadad, Ido Kaminer, Aharon Elitzur, Eliahu Cohen
This paper revisits the geometric foundations of electromagnetic theory, by studying Faraday's concept of field lines. We introduce "covariant electromagnetic field lines," a novel construct that extends traditional field line concepts to a covariant framework. Our work includes the derivation of a closed-form formula for the field line curvature in proximity to a moving electric charge, showcasing the curvature is always non-singular, including nearby a point charge. Our geometric framework leads to a geometric derivation of the Lorentz force equation and its first-order corrections, circumventing the challenges of self-force singularities and providing insights into the problem of radiation-reaction. This study not only provides a fresh geometric perspective on electromagnetic field lines but also opens avenues for future research in fields like quantum electrodynamics, gravitational field theory, and beyond.
Show moreDec 2023 • Advanced Materials Technologies
Elina Haimov‐Talmoud, Michal Rosenberg, Sofia Arshavsky‐Graham, Eli Varon, Orit Shefi, Ester Segal
Highly localized photodynamic therapy (PDT) is achieved by biolistic delivery of photosensitizer-loaded porous silicon microparticles directly into solid tumors, as demonstrated by Orit Shefi, Ester Segal, and co-workers in article 2300877. PDT irradiation following the uptake of the released photosensitizer payload induce substantial inhibition of tumor growth in vivo, opening new possibilities for an improved clinical PDT treatment.
Show moreDec 2023 • Israel Journal of Chemistry 63 (12), e202400002, 2023
Adi Salomon, Malachi Noked, Menny Shalom
Surface characterization is essential for understanding chemical and electrochemical transformations occurring on surfaces or at interfaces. Battery electrode aging processes, biofilm growth, crystallization, and transport/signaling across cellular membranes are only a few examples of such phenomena. This special issue delves into applied electrochemistry and nonlinear optical techniques applicable to surface characterization.
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