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Feb 2024 • arXiv preprint arXiv:2402.14023

25-Fold Resolution Enhancement of X-ray Microscopy Using Multipixel Ghost Imaging

O Sefi, A Ben Yehuda, Y Klein, S Bloch, H Schwartz, E Cohen, S Shwartz

Hard x-ray imaging is indispensable across diverse fields owing to its high penetrability. However, the resolution of traditional x-ray imaging modalities, such as computed tomography (CT) systems, is constrained by factors including beam properties, the absence of optical components, and detection resolution. As a result, typical resolution in commercial imaging systems is limited to a few hundred microns. This study advances high-photon-energy imaging by extending the concept of computational ghost imaging to multipixel ghost imaging with x-rays. We demonstrate a remarkable enhancement in resolution from 500 microns to approximately 20 microns for an image spanning 0.9 by 1 cm^2, comprised of 400,000 pixels and involving only 1000 realizations. Furthermore, we present a high-resolution CT reconstruction using our method, revealing enhanced visibility and resolution. Our achievement is facilitated by an innovative x-ray lithography technique and the computed tiling of images captured by each detector pixel. Importantly, this method can be scaled up for larger images without sacrificing the short measurement time, thereby opening intriguing possibilities for noninvasive high-resolution imaging of small features that are invisible with the present modalities.

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Feb 2024 • Journal of The Electrochemical Society

Protective Al2O3 Thin Film Coating by ALD to Enhance the Anodic Stability of Metallic Current Collectors in Ethereal Mg Electrolyte Solutions

Ananya Maddegalla, Yogendra Kumar, Sri Harsha Akella, Sarah Taragin, Dmitry Brav-Zhivotovksii, Hari Krishna Sadhanala, Doron Aurbach, Malachi Noked

Organometallic complex-based magnesium electrolytes in ethereal solutions have been extensively studied in the context of rechargeable magnesium batteries (RMBs) due to their ability to facilitate highly reversible magnesium deposition while demonstrating wide enough electrochemical stability windows. However, these solutions containing a unique mixture of organo-halo aluminate complexes have a detrimental effect on the anodic stability of metallic current collectors for cathodes, like Ni and Al foils. We were able to synthesize and isolate Mg2Cl3(THF)6Ph2AlCl2/THF electrolyte as the sole electroactive species using simple precursors: Ph2AlCl and MgCl2 in THF, via atom efficient mono-chloro abstraction Schlenk technique. We characterized the anodic stability of Ni, Ni@C, Al, and Al@C current collectors by monitoring their electrochemical behavior. Additionally, we investigated the anodic stability …

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Feb 2024 • Communications Materials

Deeply subwavelength mid-infrared phase retardation with α-MoO3 flakes

Michael T Enders, Mitradeep Sarkar, Maxime Giteau, Aleksandra Deeva, Hanan Herzig Sheinfux, Mehrdad Shokooh-Saremi, Frank HL Koppens, Georgia T Papadakis

Phase retardation is a cornerstone of modern optics, yet, at mid-infrared (mid-IR) frequencies, it remains a major challenge due to the scarcity of simultaneously transparent and birefringent crystals. Most materials resonantly absorb due to lattice vibrations occurring at mid-IR frequencies, and natural birefringence is weak, calling for hundreds of microns to millimeters-thick phase retarders for sufficient polarization rotation. Here, we demonstrate mid-IR phase retardation with flakes of α-MoO3 that are more than ten times thinner than the operational wavelength, achieving 90 degrees polarization rotation within one micrometer of material. We report conversion ratios above 50% in reflection or transmission mode, and wavelength tunability by several micrometers. Our results showcase that exfoliated flakes of low-dimensional crystals can serve as a platform for mid-IR miniaturized integrated low-loss polarization control.

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Feb 2024 • Frontiers in Immunology

AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes

Andrew M Collins, Mats Ohlin, Martin Corcoran, James M Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S Gibson, Oscar L Rodriguez, Ayelet Peres, Gur Yaari, Corey T Watson, William D Lees

IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more accurate and studies of the evolution of IG genes, their allelic variants and the expressed immune repertoire is therefore facilitated.MethodsThe Adaptive Immune Receptor Repertoire Community (AIRR-C) IG Reference Sets have been developed by including only human IG heavy and light chain alleles that have been confirmed by evidence from multiple high-quality sources. To further improve AIRR-seq analysis, some alleles have been extended to deal with short 3’ or 5’ truncations that can lead them to be overlooked by alignment utilities. To avoid other challenges for analysis programs, exact paralogs (e.g. IGHV1-69*01 and IGHV1-69D*01) are only represented once in each set, though alternative sequence names are noted in accompanying metadata.Results and discussionThe Reference Sets include less than half the previously recognised IG alleles (e.g. just 198 IGHV sequences), and also include a number of novel alleles: 8 IGHV alleles, 2 IGKV alleles and 5 IGLV alleles. Despite their smaller sizes, erroneous calls were eliminated, and excellent coverage was achieved when a set of repertoires comprising over 4 million V(D)J rearrangements from 99 individuals were analyzed using the Sets. The version-tracked AIRR-C IG Reference Sets are freely available at the OGRDB website (https://ogrdb.airr-community.org/germline_sets/Human) and will be regularly updated to include newly …

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Feb 2024 • Journal of the Electrochemical Society

Protective Al2O3 Thin Film Coating by ALD to Enhance the Anodic Stability of Metallic Current Collectors in Ethereal Mg Electrolyte Solutions

Ananya Maddegalla, Yogendra Kumar, Sri Harsha Akella, Sarah Taragin, Dmitry Bravo-Zhivotovskii, Hari Krishna Sadhanala, Doron Aurbach, Malachi Noked

Rechargeable magnesium batteries (RMBs) have the potential to contribute towards alternative energy storage due to their low cost, high abundance, dendrites free deposition of Mg and high volumetric energy density. Organometallic complex-based electrolytes in ethereal solutions have been extensively studied in the context of RMBs due to their ability to facilitate highly reversible magnesium deposition in rechargeable magnesium batteries, while demonstrating wide enough electrochemical stability windows. However, these solutions containing unique mixture of organo-halo aluminate complexes have detrimental effect on the anodic stability of metallic current collectors for cathodes, like Ni and Al foils. In this work, we were able to synthesize and isolate Mg 2 Cl 3 (THF) 6 Ph 2 AlCl 2/THF electrolyte as the sole electroactive species using simple precursors: Ph 2 AlCl and MgCl 2 in THF, via atom efficient mono …

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Feb 2024 • NPJ Genomic Medicine

DNA and RNA base editors can correct the majority of pathogenic single nucleotide variants

Ariel Dadush, Rona Merdler-Rabinowicz, David Gorelik, Ariel Feiglin, Ilana Buchumenski, Lipika R Pal, Shay Ben-Aroya, Eytan Ruppin, Erez Y Levanon

The majority of human genetic diseases are caused by single nucleotide variants (SNVs) in the genome sequence. Excitingly, new genomic techniques known as base editing have opened efficient pathways to correct erroneous nucleotides. Due to reliance on deaminases, which have the capability to convert A to I(G) and C to U, the direct applicability of base editing might seem constrained in terms of the range of mutations that can be reverted. In this evaluation, we assess the potential of DNA and RNA base editing methods for treating human genetic diseases. Our findings indicate that 62% of pathogenic SNVs found within genes can be amended by base editing; 30% are G>A and T>C SNVs that can be corrected by DNA base editing, and most of them by RNA base editing as well, and 29% are C>T and A>G SNVs that can be corrected by DNA base editing directed to the complementary strand. For each, we …

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Feb 2024 • Results in Physics

Confirming X-ray parametric down conversion by time–energy correlation

Nicholas John Hartley, Daniel Hodge, Taylor Buckway, Ryan Camacho, Paul Chow, Eric Christie, Arianna Gleason, Siegfried Glenzer, Aliaksei Halavanau, Abi Mae Hardy, Colin Recker, Sean Sheehan, Sharon Shwartz, Hilary Tarvin, Michael Ware, Joseph Wunschel, Yuming Xiao, RL Sandberg, Gary Walker

We present measurements of X-ray Parametric Down Conversion at the Advanced Photon Source synchrotron facility. Using an incoming pump beam at 22 keV, we observe the simultaneous, elastic emission of down-converted photon pairs generated in a diamond crystal. The pairs are detected using high count rate silicon drift detectors with low noise. Production by down-conversion is confirmed by measuring time–energy correlations in the detector signal, where photon pairs within an energy window ranging from 10 to 12 keV are only observed at short time differences. By systematically varying the crystal misalignment and detector positions, we obtain results that are consistent with the constant total of the down-converted signal. Our maximum rate of observed pairs was 130/h, corresponding to a conversion efficiency for the down-conversion process of 5. 3±0. 5× 1 0− 13.

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Jan 2024 • Results in Physics

Generic arrays of surface-positioned and shallow-buried gold multi-shapes as reference samples to benchmark near-field microscopes. Part 1: Applications in s-SNOM depth imaging

Binyamin Kusnetz, Jeremy Belhassen, Denis E Tranca, Stefan G Stanciu, Stefan-Razvan Anton, Zeev Zalevsky, George A Stanciu, Avi Karsenty

A wide palette of nanoscale imaging techniques operating in the near-field regime has been reported to date, enabling an important number of scientific breakthroughs. While the tuning and benchmarking of near-field microscopes represent a very important step for optimizing the outputs of the imaging sessions, no generally acknowledged standards exist yet in terms of calibration of near-field microscopes, which would play an important role in fully exploiting the potential of these instruments. With this work, we aim to contribute to filling in this gap, by introducing a prototypical sample, that holds potential for becoming a benchmark with respect to comparing the performances of diverse near-field measurement techniques, including traditional, aperture based, scanning near field microscopy (SNOM), or apertureless variants, such as scattering-type scanning nearfield optical microscopy (s-SNOM). The proposed …

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Jan 2024 • Journal of The Electrochemical Society

Aqueous Casting of Polymeric Electrolyte Membranes for Solid Rechargeable Na Batteries

Gayathri peta, Nagaprasad Reddy Samala, Ortal Breuer, Rajashree Konar, Yuval Elias, Ilya Grinberg, Miryam Fayena-Greenstein, Doron Aurbach

Organic solid electrolytes for rechargeable batteries are usually produced by dissolving or suspending all components and casting. For decades, acetonitrile has been widely used despite its rapid reaction with alkali metals, forming toxic products such as cyanide. Using large amounts of acetonitrile for industrial applications may pose health and environmental concerns. In addition, researchers claim that even if the solid electrolyte membranes contain residual trace water, this may positively affect the transport properties of Na ions in PEO, and those batteries with electrolytes containing trace water showed significantly improved electrochemical performance. Here, an aqueous medium was considered for casting solid polymer electrolyte membranes. Na ions conducting membranes produced with water were characterized and compared to traditional ones, produced with organic solvents. Spectral studies and …

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Jan 2024 • Molecular Therapy-Nucleic Acids

A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases

Nina Schneider, Ricky Steinberg, Amit Eylon, Johanna Valensi, Galit Kadoch, Zohar Rosenwasser, Eyal Banin, Erez Y Levanon, Dror Sharon, Shay Ben-Aroya

Adenosine deaminase acting on RNA (ADAR) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to re-code makes ADAR an attractive therapeutic tool to edit genetic mutations and reprogram genetic information at the mRNA level. Utilizing the endogenous ADARs, and guiding them to a selected target has a promising therapeutic potential. Indeed, different studies have reported several site-directed RNA editing approaches for making targeted base changes in RNA molecules. The basic strategy has been to use guide-RNAs (gRNAs) that hybridize and form a dsRNA structure with the desired RNA target due to ADAR activity in regions of dsRNA formation. Here we report on a novel pipeline for identifying disease-causing variants as candidates for RNA editing, utilizing a yeast-based screening system to select efficient …

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Jan 2024 • Journal of Colloid and Interface Science

Ordering of ionic liquids at a charged sapphire interface: Evolution with cationic chain length

Diego Pontoni, Marco DiMichiel, Bridget M Murphy, Veijo Honkimäki, Moshe Deutsch

Abstract Hypothesis Room Temperature Ionic Liquids (RTILs) bulk's molecular layering dominates their structure also at the RTIL/sapphire interface, increasing the layer spacing with the cationic alkyl chain length n. However, the negatively-charged sapphire surface compresses the layers, increases the layering range, and affects the intra-layer structure in yet unknown ways. Experiments X-ray reflectivity (XR) off the RTIL/sapphire interface, for a broad homologous RTIL series 1-alkyl-3-methylimidazolium bis (trifluoromethansulfonyl) imide, hitherto unavailable for any RTIL. Findings RTIL layers against the sapphire, exhibit two spacings: d a and d b. d a is n-varying, follows the behavior of the bulk spacing but exhibits a downshift, thus showing significant layer compression, and over twofold polar slab thinning. The latter suggests exclusion of anions from the interfacial region due to the negative sapphire charging …

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Jan 2024 • Molecules

MolOptimizer: a molecular optimization toolkit for fragment-based drug design

Adam Soffer, Samuel Joshua Viswas, Shahar Alon, Nofar Rozenberg, Amit Peled, Daniel Piro, Dan Vilenchik, Barak Akabayov

MolOptimizer is a user-friendly computational toolkit designed to streamline the hit-to-lead optimization process in drug discovery. MolOptimizer extracts features and trains machine learning models using a user-provided, labeled, and small-molecule dataset to accurately predict the binding values of new small molecules that share similar scaffolds with the target in focus. Hosted on the Azure web-based server, MolOptimizer emerges as a vital resource, accelerating the discovery and development of novel drug candidates with improved binding properties.

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Jan 2024 • Nature Catalysis

Direct measurement of the oxygen reduction reaction kinetics on iron phthalocyanine using advanced transient voltammetry

Rifael Z Snitkoff-Sol, Or Rimon, Alan M Bond, Lior Elbaz

Platinum group metal (PGM)-free catalysts are promising candidates to replace PGM catalysts for the oxygen reduction reaction in fuel cells. While methodologies to determine the number of active sites are under intense development, experimentally quantifying the parameters governing the kinetics of the reaction remains rare, albeit its potential for paving the pathways for future catalysts development. The use of transient voltammetry to probe electrocatalytic reactions by varying the measurement timescales and quantifying the reaction parameters via detailed microkinetic models has shown immense success in uncovering hidden mechanistic insights, connecting theory and experiments. Here we present the application of Fourier-transformed alternating-current voltammetry for analysis of the oxygen reduction reaction electrocatalysis on a model PGM-free catalyst, iron-phthalocyanine, to decipher the kinetic and …

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Jan 2024 • arXiv preprint arXiv:2401.09810

Properties of Fractionally Quantized Recurrence Times for Interacting Spin Models

Quancheng Liu, David A Kessler, Eli Barkai

Recurrence time quantifies the duration required for a physical system to return to its initial state, playing a pivotal role in understanding the predictability of complex systems. In quantum systems with subspace measurements, recurrence times are governed by Anandan-Aharonov phases, yielding fractionally quantized recurrence times. However, the fractional quantization phenomenon in interacting quantum systems remains poorly explored. Here, we address this gap by establishing universal lower and upper bounds for recurrence times in interacting spins. Notably, we investigate scenarios where these bounds are approached, shedding light on the speed of quantum processes under monitoring. In specific cases, our findings reveal that the complex many-body system can be effectively mapped onto a dynamical system with a single quasi-particle, leading to the discovery of integer quantized recurrence times. Our research yields a valuable link between recurrence times and the number of dark states in the system, thus providing a deeper understanding of the intricate interplay between quantum recurrence, measurements, and interaction effects.

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Jan 2024 • ACS Applied Bio Materials

Protecting the Antibacterial Coating of Urinal Catheters for Improving Safety

Ilana Perelshtein, Sivan Shoshani, Gila Jacobi, Michal Natan, Nataliia Dudchenko, Nina Perkas, Maria Tkachev, Rossella Bengalli, Luisa Fiandra, Paride Mantecca, Kristina Ivanova, Tzanko Tzanov, Ehud Banin, Aharon Gedanken

Catheter-associated urinary tract infections (CAUTI) are among the most common bacterial infections associated with prolonged hospitalization and increased healthcare expenditures. Despite recent advances in the prevention and treatment of these infections, there are still many challenges remaining, among them the creation of a durable catheter coating, which prevents bacterial biofilm formation. The current work reports on a method of protecting medical tubing endowed with antibiofilm properties. Silicone catheters coated sonochemically with ZnO nanoparticles (NPs) demonstrated excellent antibiofilm effects. Toward approval by the European Medicines Agency, it was realized that the ZnO coating would not withstand the regulatory requirements of avoiding dissolution for 14 days in artificial urine examination. Namely, after exposure to urine for 14 days, the coating amount was reduced by 90%. Additional …

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Jan 2024 • Optica Open, 2024

Multiplexed Processing of Quantum Information Across an Ultra-wide Optical Bandwidth

Avi Pe'er, Alon Eldan, Ofek Gilon, Asher Lagemi, Elai Fishman-Furman

Protocols of quantum information processing are the foundation of quantum technology, allowing to share secrets at a distance for secure communication (quantum key distribution), to teleport quantum states, and to implement quantum computation. While various protocols have already been realized, and even commercialized, the throughput and processing speed of standard protocols is generally low, limited by the narrow electronic bandwidth of the measurement apparatus in the MHz-to-GHz range, which is orders-of-magnitude lower than the optical bandwidth of available quantum optical sources (10-100 THz). We present a general concept and methods to process quantum information in parallel over multiplexed frequency channels using parametric homodyne detection for measurement of all the channels simultaneously, thereby harnessing the optical bandwidth for quantum information in an efficient …

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Jan 2024 • Materials

Synthesis and Characterization of Porous Hydrophobic and Hydrophilic Silica Microcapsules for Applications in Agriculture

Yeela Elbaz, Taly Iline-Vul, Aviv Dombrovsky, Ayelet Caspi, Shlomo Margel

Silica (SiO2) particles are widely used in various industries due to their chemical inertness, thermal stability, and wear resistance. The present study describes the preparation and potential use of porous hydrophobic and hydrophilic SiO2 microcapsules (MCs) of a narrow size distribution. First, various layers of SiO2 micro/nano-particles (M/NPs) were grafted onto monodispersed polystyrene (PS) microspheres of a narrow size distribution. Hydrophobic and hydrophilic sintered SiO2 MCs were then prepared by removing the core PS from the PS/SiO2 core–shell microspheres by burning offunder normal atmospheric conditions or organic solvent dissolution, respectively. We examined how the size and quantity of the SiO2 M/NPs influence the MC’s properties. Additionally, we utilized two forms of hollow SiO2 MC for different applications; one form was incorporated into polymer films, and the other was free-floating …

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Jan 2024 • Cells

Structure–Function Correlation in Cobalt-Induced Brain Toxicity

Basel Obied, Stephen Richard, Alon Zahavi, Dror Fixler, Olga Girshevitz, Nitza Goldenberg-Cohen

Cobalt toxicity is difficult to detect and therefore often underdiagnosed. The aim of this study was to explore the pathophysiology of cobalt-induced oxidative stress in the brain and its impact on structure and function. Thirty-five wild-type C57B16 mice received intraperitoneal cobalt chloride injections: a single high dose with evaluations at 24, 48, and 72 h (n= 5, each) or daily low doses for 28 (n= 5) or 56 days (n= 15). A part of the 56-day group also received minocycline (n= 5), while 10 mice served as controls. Behavioral changes were evaluated, and cobalt levels in tissues were measured with particle-induced X-ray emission. Brain sections underwent magnetic resonance imaging (MRI), electron microscopy, and histological, immunohistochemical, and molecular analyses. High-dose cobalt caused transient illness, whereas chronic daily low-dose administration led to long-term elevations in cobalt levels …

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Jan 2024 • Journal of Vacuum Science & Technology B

Doping engineering: Next step toward room temperature performance of terahertz quantum cascade lasers

Nathalie Lander Gower, Shiran Levy, Silvia Piperno, Sadhvikas J Addamane, John L Reno, Asaf Albo

We hereby offer a comprehensive analysis of various factors that could potentially enable terahertz quantum cascade lasers (THz QCLs) to achieve room temperature performance. We thoroughly examine and integrate the latest findings from recent studies in the field. Our work goes beyond a mere analysis; it represents a nuanced and comprehensive exploration of the intricate factors influencing the performance of THz QCLs. Through a comprehensive and holistic approach, we propose novel insights that significantly contribute to advancing strategies for improving the temperature performance of THz QCLs. This all-encompassing perspective allows us not only to present a synthesis of existing knowledge but also to offer a fresh and nuanced strategy to improve the temperature performance of THz QCLs. We draw new conclusions from prior works, demonstrating that the key to enhancing THz QCL temperature …

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Jan 2024 • Physical Review A

Light that appears to come from a source that does not exist

Itamar Stern, Yakov Bloch, Einav Grynszpan, Merav Kahn, Yakir Aharonov, Justin Dressel, Eliahu Cohen, John C Howell

Superoscillatory, band-limited functions oscillate faster than their fastest Fourier component. Superoscillations have been intensively explored recently as they give rise to many out-of-the-spectrum phenomena entailing both fundamental and applied significance. We experimentally demonstrate a form of superoscillations which is manifested by light apparently coming from a source located far away from the actual one. These superoscillations are sensed through sharp transverse shifts in the local wave vector at the minima of a pinhole diffraction pattern. We call this phenomenon “optical ventriloquism.”

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Jan 2024 • Physical Review Materials

Film morphology and substrate strain contributions to ramp reversal memory in

Avital Fried, Elihu Anouchi, Gili Cohen Taguri, Jonathan Shvartzberg, Amos Sharoni

The ramp reversal memory (RRM) effect that appears in thin films with temperature-driven insulator-metal transitions (IMTs) is a nonvolatile memory effect induced by a simple reversal of temperature ramping from heating to cooling during the phase-coexistence state of the IMT (when both metallic and insulating domains coexist). The memory of specific temperatures can be recorded by this ramp reversal, which appears as a resistance increase around the reversal temperatures. Previous studies showed RRM in , and , indicating it is a general effect in relevant systems. These studies indicate the RRM originates from an increase in the critical temperature around phase boundaries of the coexisting metallic and insulating domains during the temperature ramp reversal. However, the physical mechanism responsible for the increase remains elusive. To enhance our understanding of the effect and provide …

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