BINA

The concept of weak value exhibits numerous intriguing characteristics, leading to unexpected and potentially advantageous phenomena. In this paper, we analyze, from a computational perspective, the performance of the weak measurement protocol for measuring the weak value within various noise channels. A mathematical framework is developed for addressing the less explored case of noise acting on the primary rather than probe system. We pinpoint specific instances where the sensitivity to noise is reduced quadratically with the weak measurement protocol while this cannot be achieved with the standard measurement protocol. Specifically, when confronted with the challenge of learning an operator under the influence of either a Pauli noise channel, a unital noise channel, or an amplitude and phase damping channel, the weak measurement of the weak value can yield significant benefits. Notably, in the first two cases, and especially in the context of the unital noise channel, initializing the system in the maximally mixed state (but postselecting it in a pure state) has proven to be particularly advantageous.

The ramp reversal memory (RRM) effect that appears in thin films with temperature-driven insulator-metal transitions (IMTs) is a nonvolatile memory effect induced by a simple reversal of temperature ramping from heating to cooling during the phase-coexistence state of the IMT (when both metallic and insulating domains coexist). The memory of specific temperatures can be recorded by this ramp reversal, which appears as a resistance increase around the reversal temperatures. Previous studies showed RRM in V O 2, V 2 O 3, and NdNi O 3, indicating it is a general effect in relevant systems. These studies indicate the RRM originates from an increase in the critical temperature around phase boundaries of the coexisting metallic and insulating domains during the temperature ramp reversal. However, the physical mechanism responsible for the T C increase remains elusive. To enhance our understanding of the …

The non-Markovian continuous-time random walk model, featuring fat-tailed waiting times and narrow distributed displacements with a non-zero mean, is a well studied model for anomalous diffusion. Using an analytical approach, we recently demonstrated how a fractional space advection diffusion asymmetry equation, usually associated with Markovian Lévy flights, describes the spreading of a packet of particles. Since we use Gaussian statistics for jump lengths though fat-tailed distribution of waiting times, the appearance of fractional space derivatives in the kinetic equation demands explanations provided in this manuscript. As applications we analyse the spreading of tracers in two dimensions, breakthrough curves investigated in the field of contamination spreading in hydrology and first passage time statistics. We present a subordination scheme valid for the case when the mean waiting time is finite and the …

The Sachdev-Ye-Kitaev model (SYK) is renowned for its short-time chaotic behavior, which plays a fundamental role in its application to various fields such as quantum gravity and holography. The Thouless energy, representing the energy scale at which the universal chaotic behavior in the energy spectrum ceases, can be determined from the spectrum itself. When simulating the SYK model on classical or quantum computers, it is advantageous to minimize the number of terms in the Hamiltonian by randomly pruning the couplings. In this paper, we demonstrate that even with a significant pruning, eliminating a large number of couplings, the chaotic behavior persists up to short time scales This is true even when only a fraction of the original couplings in the fully connected SYK model, specifically , is retained. Here, represents the number of sites, and . The properties of the long-range energy scales, corresponding to short time scales, are verified through numerical singular value decomposition (SVD) and level number variance calculations.

Adenosine deaminase acting on RNA (ADAR) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to re-code makes ADAR an attractive therapeutic tool to edit genetic mutations and reprogram genetic information at the mRNA level. Utilizing the endogenous ADARs, and guiding them to a selected target has a promising therapeutic potential. Indeed, different studies have reported several site-directed RNA editing approaches for making targeted base changes in RNA molecules. The basic strategy has been to use guide-RNAs (gRNAs) that hybridize and form a dsRNA structure with the desired RNA target due to ADAR activity in regions of dsRNA formation. Here we report on a novel pipeline for identifying disease-causing variants as candidates for RNA editing, utilizing a yeast-based screening system to select efficient …

In this era of advanced technology and innovation, infectious diseases still cause significant morbidity and mortality, which need to be addressed. Despite overwhelming success in the development of vaccines, transmittable diseases such as tuberculosis and AIDS remain unprotected, and the treatment is challenging due to frequent mutations of the pathogens. Formulations of new or existing drugs with polymeric materials have been explored as a promising new approach. Variations in shape, size, surface charge, internal morphology, and functionalization position polymer particles as a revolutionary material in healthcare. Here, an overview is provided of major diseases along with statistics on infection and death rates, focusing on polymer-based treatments and modes of action. Key issues are discussed in this review pertaining to current challenges and future perspectives.

Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI Page 1 PROGRESS IN BIOMEDICAL OPTICS AND IMAGING Vol. 25 No. 43 Volume 12858 Proceedings of SPIE, 1605-7422, V. 12858 SPIE is an international society advancing an interdisciplinary approach to the science and application of light. Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI Dror Fixler Sebastian Wachsmann-Hogiu Editors 28 January 2024 San Francisco, California, United States Sponsored by SPIE Cosponsored by Prizmatix Ltd. (Israel) Published by SPIE Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI, edited by Dror Fixler, Sebastian Wachsmann-Hogiu, Proc. of SPIE Vol. 12858, 1285801 © 2024 SPIE · 1605-7422 · doi: 10.1117/12.3030104 Proc. of SPIE Vol. 12858 1285801-1 Page 2 The papers in this volume were part of the technical conference cited on the …

Membrane protein biogenesis poses acute challenges to protein homeostasis, and how they are selectively escorted to the target membrane is not well understood. Here we address this question in the guided-entry-of-tail-anchored protein (GET) pathway, in which tail-anchored membrane proteins (TAs) are relayed through an Hsp70-Sgt2-Get3 chaperone triad for targeting to the endoplasmic reticulum. We show that the Hsp70 ATPase cycle and TA substrate drive dimeric Sgt2 from a wide-open conformation to a closed state, in which TAs are protected by both substrate binding domains of Sgt2. Get3 is privileged to receive TA from closed Sgt2, whereas off-pathway chaperones remove TAs from open Sgt2. Sgt2 closing is less favorable with suboptimal GET substrates, which are rejected during or after the Hsp70-to-Sgt2 handover. Our results demonstrate how fine-tuned conformational dynamics in Sgt2 enable …

Rechargeable Mg‐ion Batteries (RMB) containing a Mg metal anode offer the promise of higher specific volumetric capacity, energy density, safety, and economic viability than lithium‐ion battery technology, but their realization is challenging. The limited availability of suitable inorganic cathodes compatible with electrolytes relevant to Mg metal anode restricts the development of RMBs. Despite the promising capability of some oxides to reversibly intercalate Mg+2 ions at high potential, its lack of stability in chloride‐containing ethereal electrolytes, relevant to Mg metal anode hinders the realization of a full practical RMB. Here the successful in situ encapsulation of monodispersed spherical V2O5 (≈200 nm) is demonstrated by a thin layer of VS2 (≈12 nm) through a facile surface reduction route. The VS2 layer protects the surface of V2O5 particles in RMB electrolyte solution (MgCl2 + MgTFSI in DME). Both V2O5 …

Infectious diseases are one of the world’s leading causes of morbidity. Their rapid spread emphasizes the need for accurate and fast diagnostic methods for large-scale screening. Here, we describe a robust method for the detection of pathogens based on microscale thermophoresis (MST). The method involves the hybridization of a fluorescently labeled DNA probe to a target RNA, and the assessment of thermophoretic migration of the resulting complex in solution within a 2-30 second time window. We found that the thermophoretic migration of the nucleic acid-based probes is primarily determined by the fluorescent molecule used, rather than the nucleic acid sequence of the probe. Furthermore, a panel of uniformly labeled probes that bind to the same target RNA yields a more responsive detection pattern than a single probe, and moreover, can be used for detection of specific pathogen variants. In addition …

Magnesium batteries have attracted considerable attention as a promising technology for future energy storage because of their capability to undergo multiple charging reactions. However, most oxide materials utilized as hosts for magnesium batteries do not perform well at room temperature or in nonaqueous electrolytes. Herein, a host material, Na0.04MoO3·(H2O)0.49 is successfully developed through the chemical reduction of alpha‐MoO3, which enables magnesium storage reaction in a 0.5 m Mg(ClO4)2/acetonitrile electrolyte at 25 °C. Electrochemical analysis reveals that the cathode material possesses a discharge capacity of 157.4 mAh g−1 at a 0.2 C rate. The Na0.04MoO3·(H2O)0.49 cathode material also exhibits a capacity retention of 93.4% after 100 cycles compared to the first cycle at a 2 C rate, with an average discharge voltage of −0.474 V versus activated carbon (≈2.16 V estimated …

Identifying the type of structural defects and determining their concentration is crucial for effective defect engineering strategies since they govern various physical, chemical, and optoelectronic properties of graphene. Here, we study the effects of Ga ion irradiation on freestanding monolayer graphene, specifically focusing on the behavior of three defect-induced Raman lines (D, D' and (D+ D')). By employing a modified approach of the local activation model, we determine the key defect parameters of each line and show their dependence on different vibrational configurations of the iTO and iLO phonons emitted during scattering. The redshift of the lines and the broadening of their width, observed with an increase in the concentration of radiation defects over Nd ≈ 1013cm−2, are explained by the tensile stress of the graphene film and a decrease in the phonon lifetime, respectively. The resulting intensity ratio I(D)/I …

Rechargeable Mg‐ion Batteries (RMB) containing a Mg metal anode offer the promise of higher specific volumetric capacity, energy density, safety, and economic viability than lithium‐ion battery technology, but their realization is challenging. The limited availability of suitable inorganic cathodes compatible with electrolytes relevant to Mg metal anode restricts the development of RMBs. Despite the promising capability of some oxides to reversibly intercalate Mg+2 ions at high potential, its lack of stability in chloride‐containing ethereal electrolytes, relevant to Mg metal anode hinders the realization of a full practical RMB. Here the successful in situ encapsulation of monodispersed spherical V2O5 (≈200 nm) is demonstrated by a thin layer of VS2 (≈12 nm) through a facile surface reduction route. The VS2 layer protects the surface of V2O5 particles in RMB electrolyte solution (MgCl2 + MgTFSI in DME). Both V2O5 …

Recurrence time quantifies the duration required for a physical system to return to its initial state, playing a pivotal role in understanding the predictability of complex systems. In quantum systems with subspace measurements, recurrence times are governed by Anandan-Aharonov phases, yielding fractionally quantized recurrence times. However, the fractional quantization phenomenon in interacting quantum systems remains poorly explored. Here, we address this gap by establishing universal lower and upper bounds for recurrence times in interacting spins. Notably, we investigate scenarios where these bounds are approached, shedding light on the speed of quantum processes under monitoring. In specific cases, our findings reveal that the complex many-body system can be effectively mapped onto a dynamical system with a single quasi-particle, leading to the discovery of integer quantized recurrence times. Our research yields a valuable link between recurrence times and the number of dark states in the system, thus providing a deeper understanding of the intricate interplay between quantum recurrence, measurements, and interaction effects.

A major hypothesis for the etiology of type 1 diabetes (T1D) postulates initiation by viral infection, leading to double-stranded RNA (dsRNA)-mediated interferon response and inflammation; however, a causal virus has not been identified. Here, we use a mouse model, corroborated with human islet data, to demonstrate that endogenous dsRNA in beta cells can lead to a diabetogenic immune response, thus identifying a virus-independent mechanism for T1D initiation. We found that disruption of the RNA editing enzyme adenosine deaminases acting on RNA (ADAR) in beta cells triggers a massive interferon response, islet inflammation, and beta cell failure and destruction, with features bearing striking similarity to early-stage human T1D. Glycolysis via calcium enhances the interferon response, suggesting an actionable vicious cycle of inflammation and increased beta cell workload.

The development of new nanoparticle-based antibiotics with biocompatible properties is an emerging advance in nanotechnology. This study advocated the development of carbon dots (CDs) doped with nitrogen, nitrogen with sulfur, and nitrogen with boron (N, NS, and NB-CDs). This led to changes in the properties of the CDs, both chemically and biologically. A facile hydrothermal technique was used to synthesize CDs and the formation of CDs was confirmed through various analytical techniques. The CDs had sizes ranging from 3.2 – 4.8 nm and ζ-potential values of +13 to 27 mV. The doped CDs exhibited moderate changes in fluorescence behaviors depending on the excitation wavelength (λex). The N- and NB-doped CDs were effective at eliminating gram-negative pathogens (E. coli and K. pneumoniae), with minimum inhibitory concentrations (MIC) of 300 µg/mL and 400 µg/mL, respectively. The …

Superoscillatory, band-limited functions oscillate faster than their fastest Fourier component. Superoscillations have been intensively explored recently as they give rise to many out-of-the-spectrum phenomena entailing both fundamental and applied significance. We experimentally demonstrate a form of superoscillations which is manifested by light apparently coming from a source located far away from the actual one. These superoscillations are sensed through sharp transverse shifts in the local wave vector at the minima of a pinhole diffraction pattern. We call this phenomenon “optical ventriloquism.”

We demonstrate a molybdenum silicide superconducting nanowire single-photon detector heterogeneously integrated onto a thin-film lithium niobate waveguide. The detector achieves approximately 50% on-chip detection efficiency at 1550 nm with a jitter of 82 ps when measured at 0.78 K. This demonstration showcases the integration of an amorphous superconductor utilizing conventional fabrication processes without strict cooling and substrate requirements. This paves the way for the integration of additional superconducting electronic components, potentially realizing the full promise of integrated quantum photonic circuits.

We demonstrate temperature-controlled spectral tunability of a partially-pumped single-wavelength random laser in a solid-state random laser based on DCM [4-dicyanomethylene-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran] doped PMMA (polymethyl methacrylate) dye. By carefully shaping the spatial profile of the pump, we first achieve a low-threshold, single-mode random lasing with an excellent side lobe rejection. Notably, we show how temperature-induced changes in the refractive index of the PMMA-DCM layer result in a blue shift of this single lasing mode. We demonstrate spectral tunability over an 8nm-wide bandwidth.

Organic solid electrolytes for rechargeable batteries are usually produced by dissolving or suspending all components and casting. For decades, acetonitrile has been widely used despite its rapid reaction with alkali metals, forming toxic products such as cyanide. Using large amounts of acetonitrile for industrial applications may pose health and environmental concerns. In addition, researchers claim that even if the solid electrolyte membranes contain residual trace water, this may positively affect the transport properties of Na ions in PEO, and those batteries with electrolytes containing trace water showed significantly improved electrochemical performance. Here, an aqueous medium was considered for casting solid polymer electrolyte membranes. Na ions conducting membranes produced with water were characterized and compared to traditional ones, produced with organic solvents. Spectral studies and …

Abstract Hypothesis Room Temperature Ionic Liquids (RTILs) bulk's molecular layering dominates their structure also at the RTIL/sapphire interface, increasing the layer spacing with the cationic alkyl chain length n. However, the negatively-charged sapphire surface compresses the layers, increases the layering range, and affects the intra-layer structure in yet unknown ways. Experiments X-ray reflectivity (XR) off the RTIL/sapphire interface, for a broad homologous RTIL series 1-alkyl-3-methylimidazolium bis (trifluoromethansulfonyl) imide, hitherto unavailable for any RTIL. Findings RTIL layers against the sapphire, exhibit two spacings: d a and d b. d a is n-varying, follows the behavior of the bulk spacing but exhibits a downshift, thus showing significant layer compression, and over twofold polar slab thinning. The latter suggests exclusion of anions from the interfacial region due to the negative sapphire charging …