BINA

2839 articles

72 publishers

Join mailing list

Jan 2023 • Biochemistry

Conformations and Local Dynamics of the CopY Metal Sensor Revealed by EPR Spectroscopy

Melanie Hirsch, Lukas Hofmann, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sharon Ruthstein

Metal transcription factors regulate metal concentrations in eukaryotic and prokaryotic cells. Copper is a metal ion that is being tightly regulated, owing to its dual nature. Whereas copper is an essential nutrient for bacteria, it is also toxic at high concentrations. CopY is a metal-sensitive transcription factor belonging to the copper-responsive repressor family found in Gram-positive bacteria. CopY represses transcription in the presence of Zn(II) ions and initiates transcription in the presence of Cu(I) ions. The complete crystal structure of CopY has not been reported yet, therefore most of the structural information on this protein is based on its similarity to the well-studied MecI protein. In this study, electron paramagnetic resonance (EPR) spectroscopy was used to characterize structural and local dynamical changes in Streptococcus pneumoniae CopY as a function of Zn(II), Cu(I), and DNA binding. We detected different …

Show more

Jan 2023 • Journal of the American Chemical Society

Direct Quinone Fuel Cells

Yan Yurko, Lior Elbaz

The increasing interest and need to shift to sustainable energy give rise to the utilization of fuel cell technologies in various applications. The challenging task of hydrogen storage and transport led to the development of liquid hydrogen carriers (LHCs) as fuels for direct LHC fuel cells, such as methanol in direct methanol fuel cells (DMFCs). Although simpler to handle, most direct LHC fuel cells suffer from durability and price issues derived from high catalysts’ loadings and byproducts of the oxidation reaction of the fuel. Herein, we report on the development of direct hydroquinone fuel cells (DQFCs) based on anthraquinone-2,7-disulfonic acid (AQDS) as an LHC. We have shown that DQFC can operate with a continuous flow of quinone as a hydrogen carrier, outperforming the incumbent state-of-the-art DMFC by a factor of 3 in peak power density while completely removing the need for any catalyst at the anode. In …

Show more

Jan 2023 • Nanomaterials 13 (3), 598, 2023

Recent Advances in the Spintronic Application of Carbon-Based Nanomaterials

Shweta Pawar, Hamootal Duadi, Dror Fixler

The term “carbon-based spintronics” mostly refers to the spin applications in carbon materials such as graphene, fullerene, carbon nitride, and carbon nanotubes. Carbon-based spintronics and their devices have undergone extraordinary development recently. The causes of spin relaxation and the characteristics of spin transport in carbon materials, namely for graphene and carbon nanotubes, have been the subject of several theoretical and experimental studies. This article gives a summary of the present state of research and technological advancements for spintronic applications in carbon-based materials. We discuss the benefits and challenges of several spin-enabled, carbon-based applications. The advantages include the fact that they are significantly less volatile than charge-based electronics. The challenge is in being able to scale up to mass production.

Show more

Jan 2023 • Journal of the American Chemical Society

Direct Quinone Fuel Cells

Yan Yurko, Lior Elbaz

The increasing interest and need to shift to sustainable energy give rise to the utilization of fuel cell technologies in various applications. The challenging task of hydrogen storage and transport led to the development of liquid hydrogen carriers (LHCs) as fuels for direct LHC fuel cells, such as methanol in direct methanol fuel cells (DMFCs). Although simpler to handle, most direct LHC fuel cells suffer from durability and price issues derived from high catalysts’ loadings and byproducts of the oxidation reaction of the fuel. Herein, we report on the development of direct hydroquinone fuel cells (DQFCs) based on anthraquinone-2,7-disulfonic acid (AQDS) as an LHC. We have shown that DQFC can operate with a continuous flow of quinone as a hydrogen carrier, outperforming the incumbent state-of-the-art DMFC by a factor of 3 in peak power density while completely removing the need for any catalyst at the anode. In …

Show more

2023 • RSC Advances

Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction

Meir Abuaf, Subhomoy Das, Yitzhak Mastai

Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based on various chiral amino acid derivatives and characterized by dynamic light scattering and scanning electron microscopy. The nanoparticles with spherical structure between 250 and 400 nm and high chiral surface area were used as catalysts in the aldol reaction at room temperature without additional solvent. L-tryptophan gave the highest enantiomeric excess, >86% with similar catalytic performance four times.

Show more

2023 • FRONTIERS IN ONCOLOGY 12, 2023

A predictive model for personalization of nanotechnology-based phototherapy in cancer treatment

Eli Varon, Gaddi Blumrosen, Orit Shefi

Cancer remains a leading cause of death globally (1). The conventional methods of treatment offered are radiation (2), chemotherapy (3), immunotherapy (4), surgery, and recently nanotechnology (nanomedicine and nano-processes)(5). Every cancer treatment can be defined and evaluated based on its efficiency, selectivity, side effects, and economic cost (6). However, combining predictive models and advanced machine learning methods with these cancer therapies may enhance their overall efficiency and selectivity, as well as the safety of the patient.Radiation Therapy (RT), also known as radiotherapy, is a non-surgical intervention frequently used in cancer treatment (2). This method is based on a high-level focused dose of radiation directed toward the tumor. This deposit of highenergy radiation kills cancer cells or decelerates their growth by damaging their DNA (2). Nevertheless, the challenges of RT include damage to tumor-proximate normal cells, the inability to radiate minor tumors out of scope of the imaging scans, patient movement, and low oxygen supply (7, 8). Therefore, many researchers are working on the development of targeted radiation methods to deliver a higher dose of radiation to the tumor with improved selectivity. Recently, the combination of nanotechnology with laser radiation has been demonstrated to represent a safe set of modalities for tumor destruction with high specificity (9). In particular, this involves the use of light-controlled nanoparticles (NPs) that can be activated via a light of a specific wavelength to form highly efficient and selective systems in the nanometer range (10). These NPs accumulate specifically …

Show more

2023 • Journal of Materials Chemistry B

Controlled synthesis of multifunctional dome-shaped micro-and nano-structures via a robust physical route for biological applications

Ganit Indech, Lidor Geri, Chen Mordechai, Yarden Ben Moshe, Yitzhak Mastai, Orit Shefi, Amos Sharoni

Micro- and Nano-particles are elemental for many current and developing technologies. Specifically, these particles are being extensively used in biological studies and applications, including imaging, drug delivery and therapeutics. Recent advances have led to the development of multifunctional particles, which have the potential to further enhance their effectiveness, enabling novel applications. Therefore, many efforts are devoted to produce well-defined particles for specific needs. However, conventional fabrication methodologies utilized to develop particles are time consuming, making it extremely challenging to fine-tune properties of the particles for multifunctional applications. Herein, we present a simple and facile method to fabricate dome-shaped micron and nano particles by a robust physical route. The presented method enables to design particles with a vast range of materials, sizes and compositions …

Show more

2023 • Advanced Energy Materials, 2203154, 2023

Elucidation of the Charging Mechanisms and the Coupled Structural–Mechanical Behavior of Ti3C2Tx (MXenes) Electrodes by In Situ Techniques

Gil Bergman, Elad Ballas, Qiang Gao, Amey Nimkar, Bar Gavriel, Mikhael D Levi, Daniel Sharon, Fyodor Malchik, Xuehang Wang, Netanel Shpigel, Daniel Mandler, Doron Aurbach

The discovery of the Ti3C2Tx compounds (MXenes) a decade ago opened new research directions and valuable opportunities for high‐rate energy storage applications. The unique ability of the MXenes to host various mono‐ and multivalent cations and their high stability in different electrolyte environments including aqueous, organic, and ionic liquid solutions, promoted the rapid development of advanced MXene‐based electrodes for a large variety of applications. Unlike the vast majority of typical intercalation compounds, the electrochemical performance of MXene electrodes is strongly influenced by the presence of co‐inserted solvent molecules, which cannot be detected by conventional current/potential electrochemical measurements. Furthermore, the electrochemical insertion of ions into MXene interspaces results in strong coupling with the intercalation‐induced structural, dimensional, and viscoelastic …

Show more

2023 • Journal of Materials Chemistry A

Stabilizing Ni-rich high energy cathodes for advanced lithium-ion batteries: the case of LiNi 0.9 Co 0.1 O 2

Francis Amalraj Susai, Amreen Bano, Sandipan Maiti, Judith Grinblat, Arup Chakraborty, Hadar Sclar, Tatyana Kravchuk, Aleksandr Kondrakov, Maria Tkachev, Michael Talianker, Dan Thomas Major, Boris Markovsky, Doron Aurbach

Lithiated oxides like Li[NixCoyMnz]O2 (x+y+z=1) with high nickel content (x≥0.8) can possess high specific capacity ≥ 200 mAhg-1 and have attracted extensive attention as perspective cathode materials for advanced lithium-ion batteries. In this work, we synthesized LiNi0.9Co0.1O2 (NC90) materials and studied their structural characteristics, electrochemical performance, and thermal behavior in Li-cells. We developed modified cationic-doped NC90 samples with greatly improved properties due to doping with Mo6+ and B3+ and dual doping via simultaneous modification with these dopants. The main results of the current study are significantly higher capacity retention, greatly reduced voltage hysteresis, and considerably decreased charge-transfer resistance of the Mo and Mo-B doped electrodes compared to the undoped ones upon prolonged cycling. We also revealed remarkable microstructural stability of …

Show more

2023 • Energy & Environmental Science

A practical perspective on the potential of rechargeable Mg batteries

J Alberto Blázquez, Rudi R Maça, Olatz Leonet, Eneko Azaceta, Ayan Mukherjee, Zhirong Zhao-Karger, Zhenyou Li, Aleksey Kovalevsky, Ana Fernández-Barquín, Aroa R Mainar, Piotr Jankowski, Laurin Rademacher, Sunita Dey, Siân E Dutton, Clare P Grey, Janina Drews, Joachim Häcker, Timo Danner, Arnulf Latz, Dane Sotta, M Rosa Palacin, Jean-Frédéric Martin, Juan Maria García Lastra, Maximilian Fichtner, Sumana Kundu, Alexander Kraytsberg, Yair Ein-Eli, Malachi Noked, Doron Aurbach

Emerging energy storage systems based on abundant and cost-effective materials are key to overcome the global energy and climate crisis of the 21st century. Rechargeable Magnesium Batteries (RMB), based on Earth-abundant magnesium, can provide a cheap and environmentally responsible alternative to the benchmark Li-ion technology, especially for large energy storage applications. Currently, RMB technology is the subject of intense research efforts at laboratory scale. However, these emerging approaches must be placed in a real-world perspective to ensure that they satisfy key technological requirements. In an attempt to bridge the gap between laboratory advancements and industrial development demands, herein, we report the first non-aqueous multilayer RMB pouch cell prototypes and propose a roadmap for a new advanced RMB chemistry. Through this work, we aim to show the great unrealized …

Show more

2023 • Volume

Image Quantification in Biology: A Short Commentary on Statistical Parametrization of Cell Cytoskeleton (SPOCC), 21st Century Pathology

S Weiss

Imaging and microscopy have played a very important role in biological research. In this commentary, we have provided a summary of the development of different imaging modalities and quantitative techniques as an introduction. We have briefly described the technique Statistical Parametrization of Cell Cytoskeleton (SPOCC) and evaluated it against similar techniques available. We have also discussed the advantages, short comings and future prospective of SPOCC both technically and biologically.

Show more

2023 • Journal of Materials Chemistry B

Controlled synthesis of multifunctional dome-shaped micro-and nano-structures via a robust physical route for biological applications

Ganit Indech, Lidor Geri, Chen Mordechai, Yarden Ben Moshe, Yitzhak Mastai, Orit Shefi, Amos Sharoni

Micro- and Nano-particles are elemental for many current and developing technologies. Specifically, these particles are being extensively used in biological studies and applications, including imaging, drug delivery and therapeutics. Recent advances have led to the development of multifunctional particles, which have the potential to further enhance their effectiveness, enabling novel applications. Therefore, many efforts are devoted to produce well-defined particles for specific needs. However, conventional fabrication methodologies utilized to develop particles are time consuming, making it extremely challenging to fine-tune properties of the particles for multifunctional applications. Herein, we present a simple and facile method to fabricate dome-shaped micron and nano particles by a robust physical route. The presented method enables to design particles with a vast range of materials, sizes and compositions …

Show more

2023 • Bioengineering & Translational Medicine

Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair

Jingyan Yi, Xin Luo, Jinshan Xing, Aharon Gedanken, Xiukun Lin, Chunxiang Zhang, Gan Qiao

Micelle Encapsulation Zinc‐doped copper oxide nanocomposites (MEnZn‐CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn‐CuO NPs) using non‐micellar beam. Compared with Zn‐CuO NPs, MEnZn‐CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn‐CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn‐CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP‐ribose) polymerase inhibitors for lethal effects.

Show more

2023 • Advanced Optical Materials

Characterization of Nanometric Thin Films with Far‐Field Light

Hodaya Klimovsky, Omer Shavit, Carine Julien, Ilya Olevsko, Mohamed Hamode, Yossi Abulafia, Hervé Suaudeau, Vincent Armand, Martin Oheim, Adi Salomon

The characterization of ultrathin transparent films is paramount for various optoelectronic materials, coatings, and photonics. However, characterizing such thin layers is difficult and it requires specialized clean‐room equipment and trained personnel. Here, a contact‐less, all‐optical method is introduced and validated for characterizing nanometric transparent films using far‐field optics. A series of nanometric, smooth, and homogeneous layered samples are fabricated first, alternating transparent spacer and fluorescent layers in a controlled manner. Fluorescence radiation pattern originating from the thin fluorophore layers is then recorded and analyzed and quantitative image analysis is used to perform in operando measurements of the refractive index, film homogeneity and to estimate axial fluorophore distances at a sub‐wavelength scale with a precision of a few of nanometers. The results compare favorably to …

Show more

2023

Modelling of Magnesium Intercalation into Chevrel Phase

Janina Drews, Ben Dlugatch, Johannes Wiedemann, Rudi Ruben Maça, Liping Wang, J Alberto Blazquez, Zhirong Zhao-Karger, Maximilian Fichtner, Doron Aurbach, Timo Danner, Arnulf Latz

Regarding energy density, safety, cost, and sustainability rechargeable magnesium batteries are a very promising next-generation energy storage technology. However, for a successful commercialization of Mg batteries there are still some challenges to overcome. Generally, the high charge density of the bivalent cation causes strong coulomb interactions with anions and solvent molecules. Therefore, energetic barriers for desolvation and solid-state diffusion are usually very high, which can have a crucial impact on the battery performance. Former can significantly hinder the electron-transfer reaction,[1] whereas latter makes the choice of suitable cathode materials very challenging. For instance, it is wellknown that the morphology of an intercalation material can strongly influence the battery performance and smaller particles as well as thinner electrodes are common strategies for avoiding adverse effects of transport limitations. Moreover, the presence of chlorides can influence the intercalation process.[2] Up to date Chevrel phase (CP) Mo6S8 is considered as a benchmark intercalation cathode. In our contribution we carefully study this model system of a magnesium-ion battery to get a better understanding of how to overcome undesired limitations. Therefore, we present a newly-developed continuum model, which is able to describe the complex intercalation process of magnesium cations into a CP cathode (Fig. 1). The model considers not only the different thermodynamics and kinetics of the two intercalation sites of Mo6S8 and their interplay, but also the impact of the desolvation on the electrochemical reactions and possible ion …

Show more

2023 • 21st Century Pathology

Image Quantification in Biology: A Short Commentary on Statistical Parametrization of Cell Cytoskeleton (SPOCC)

Arkaprabha Basu, Shimon Weiss

Imaging and microscopy have played a very important role in biological research. In this commentary, we have provided a summary of the development of different imaging modalities and quantitative techniques as an introduction. We have briefly described the technique Statistical Parametrization of Cell Cytoskeleton (SPOCC) and evaluated it against similar techniques available. We have also discussed the advantages, short comings and future prospective of SPOCC both technically and biologically.

Show more

2023 • Advanced Therapeutics

Tumor‐Targeted Poly (ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy–In‐vivo Study

Ella Itzhaki, Eva Chausky‐Barzakh, Ayelet Atkins, Avital Bareket‐Samish, Salomon M Stemmer, Shlomo Margel, Neta Moskovits

The arginine‐glycine‐glutamic acid (RGD) sequence, an αvβ3 integrin recognition site, is overexpressed in malignancies and neovasculature, making it a potential therapeutic target. Here, we assess efficacy/safety of tumor‐targeted RGD‐based proteinoid nanocapsules (NCs) entrapping a synergistic combination of two drugs – palbociclib (Pal), a CDK4/6 inhibitor, and alpelisib (Alp), a P13K inhibitor, as a cancer treatment. P(RGD) proteinoid polymers are produced by thermal step‐growth polymerization of R, G and D under inert atmosphere. P(RGD) NCs, hollow and encapsulating 25 w% each of Pal and Alp, are formed by self‐assembly of the proteinoid polymer. The encapsulation yields of Pal and Alp were 72% and 95%, respectively. Long‐term stability, controlled release, cellular uptake, and synergistic cytotoxicity and induced cell death are evident from in‐vitro experiments. Findings from in‐vivo breast …

Show more

2023 • Nanoscale

rsc. li/nanoscale

Jessica S Freitag, Christin Möser, Robel Belay, Basma Altattan, Nico Grasse, Bhanu Kiran Pothineni, Jörg Schnauß, David M Smith, Vijay Bhooshan Kumar, Aharon Gedanken, Ze’ev Porat

Nanoscale Page 1 Nanoscale rsc.li/nanoscale The Royal Society of Chemistry is the world's leading chemistry community. Through our high impact journals and publications we connect the world with the chemical sciences and invest the profits back into the chemistry community. IN THIS ISSUE ISSN 2040-3372 CODEN NANOHL 15(17) 7595–8030 (2023) Cover See Munho Kim, Guo-En Chang et al., pp. 7745–7754. Image reproduced by permission of Guo-En Chang from Nanoscale, 2023, 15, 7745. Inside cover See Palyam Subramanyam, Vasudevanpillai Biju et al., pp. 7695–7702. Image reproduced by permission of Vasudevanpillai Biju from Nanoscale, 2023, 15, 7695. REVIEWS 7608 Integration of functional peptides into nucleic acid-based nanostructures Jessica S. Freitag, Christin Möser, Robel Belay, Basma Altattan, Nico Grasse, Bhanu Kiran Pothineni, Jörg Schnauß and David M. Smith* 7625 …

Show more

2023 • bioRxiv

Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

Marlon S Zambrano-Mila, Monika Witzenberger, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Levanon, Schraga Schwartz

Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and ADAR2, modulating double-stranded RNA (dsRNA) immunogenicity and recoding mRNA. The high variability in the susceptibility of different adenosines to editing begs the question of what are the determinants of substrate specificity. Here, we systematically monitor how secondary structure modulates ADAR2 vs ADAR1 substrate selectivity, on the basis of systematic probing of thousands of synthetic sequences transfected into ADAR1-deleted cell lines exogenously expressing either ADAR2 or ADAR1. In both cases, structural disruptions gave rise to symmetric, strand-specific induced editing at a fixed offset, but of varying length: -26 nt for ADAR2, and -35 nt for ADAR1. We dissect the basis for the differences in offset between ADAR1 and ADAR2 via diverse mutants, domain-swaps, and ADAR evolutionary homologs, and reveal that it is encoded by the differential RNA binding domain architecture. We demonstrate that this offset-enhanced editing can allow an improved design of ADAR2-recruiting therapeutics, with proof-of-concept experiments suggestive of increased on-target and potentially decreased off-target editing. Our findings provide novel insight into the determinants guiding ADAR2 substrate selectivity and into the roles of the RNA binding domains of ADAR1 and ADAR2 in mediating differential targeting, and should facilitate the design of improved ADAR-recruiting therapeutics.

Show more

2023 • Advanced Materials Interfaces

Combinatorial Vacuum‐Deposition of Wide Bandgap Perovskite Films and Solar Cells

Isidora Susic, Adi Kama, Lidón Gil‐Escrig, Chris Dreessen, Francisco Palazon, David Cahen, Michele Sessolo, Henk J Bolink

The development of vacuum‐deposited perovskite materials and devices is partially slowed down by the minor research effort in this direction, due to the high cost of the required research tools. But there is also another factor, thermal co‐deposition in high vacuum involves the simultaneous sublimation of several precursors with an overall deposition rate in the range of few Å s−1. This leads to a deposition time of hours with only a single set of process parameters per batch, hence to a long timeframe to optimize even a single perovskite composition. Here we report the combinatorial vacuum deposition of wide bandgap perovskites using 4 sources and a non‐rotating sample holder. By using small pixel substrates, more than 100 solar cells can be produced with different perovskite absorbers in a single deposition run. The materials are characterized by spatially resolved methods, including optical, morphological …

Show more

2023 • Journal of Materials Chemistry B

Controlled synthesis of multifunctional dome-shaped micro-and nano-structures via a robust physical route for biological applications

Ganit Indech, Lidor Geri, Chen Mordechai, Yarden Ben Moshe, Yitzhak Mastai, Orit Shefi, Amos Sharoni

Micro- and Nano-particles are elemental for many current and developing technologies. Specifically, these particles are being extensively used in biological studies and applications, including imaging, drug delivery and therapeutics. Recent advances have led to the development of multifunctional particles, which have the potential to further enhance their effectiveness, enabling novel applications. Therefore, many efforts are devoted to produce well-defined particles for specific needs. However, conventional fabrication methodologies utilized to develop particles are time consuming, making it extremely challenging to fine-tune properties of the particles for multifunctional applications. Herein, we present a simple and facile method to fabricate dome-shaped micron and nano particles by a robust physical route. The presented method enables to design particles with a vast range of materials, sizes and compositions …

Show more

logo
Articali

Powered by Articali

TermsPrivacy